1-O-(6-O-toluenesulfonyl-α-D-galactopyranosyl)-2-(11-(3,4-difluorophenyl)undecanoyl)amino-D-ribo-1,3,4-octadecanetriol

Base Information

Chemical Name:1-O-(6-O-toluenesulfonyl-α-D-galactopyranosyl)-2-(11-(3,4-difluorophenyl)undecanoyl)amino-D-ribo-1,3,4-octadecanetriol
CAS No.:1384424-10-5
Molecular Formula:C₄₈H₇₇F₂NO₁₁S
Molecular Weight:914.202
Hs Code.:

Synonyms:1-O-(6-O-toluenesulfonyl-α-D-galactopyranosyl)-2-(11-(3,4-difluorophenyl)undecanoyl)amino-D-ribo-1,3,4-octadecanetriol

Suppliers and Price of 1-O-(6-O-toluenesulfonyl-α-D-galactopyranosyl)-2-(11-(3,4-difluorophenyl)undecanoyl)amino-D-ribo-1,3,4-octadecanetriol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-O-(6-O-toluenesulfonyl-α-D-galactopyranosyl)-2-(11-(3,4-difluorophenyl)undecanoyl)amino-D-ribo-1,3,4-octadecanetriol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-O-(6-O-toluenesulfonyl-α-D-galactopyranosyl)-2-(11-(3,4-difluorophenyl)undecanoyl)amino-D-ribo-1,3,4-octadecanetriol

There total 8 articles about 1-O-(6-O-toluenesulfonyl-α-D-galactopyranosyl)-2-(11-(3,4-difluorophenyl)undecanoyl)amino-D-ribo-1,3,4-octadecanetriol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 1384423-80-6
1-O-(α-D-galactopyranosyl)-2-(11-(3,4-difluorophenyl)undecanoyl)amino-D-ribo-1,3,4-octadecanetriol

: 98-59-9
p-toluenesulfonyl chloride

: 1384424-10-5
1-O-(6-O-toluenesulfonyl-α-D-galactopyranosyl)-2-(11-(3,4-difluorophenyl)undecanoyl)amino-D-ribo-1,3,4-octadecanetriol

Guidance literature:: With pyridine; at 0 - 20 ℃; for 16h;
DOI:10.1002/cbic.201200004

Reference yield:

: 1384423-95-3
11-(3,4-difluorophenyl)undecanoic acid

: 1384424-10-5
1-O-(6-O-toluenesulfonyl-α-D-galactopyranosyl)-2-(11-(3,4-difluorophenyl)undecanoyl)amino-D-ribo-1,3,4-octadecanetriol

Guidance literature:: Multi-step reaction with 3 steps

1: 4-methyl-morpholine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane / 12 h / 20 °C

2: hydrogen; palladium(II) hydroxide / methanol; dichloromethane / 12 h / 20 °C

3: pyridine / 16 h / 0 - 20 °C

With 4-methyl-morpholine; pyridine; hydrogen; palladium(II) hydroxide; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In methanol; dichloromethane;
DOI:10.1002/cbic.201200004

Reference yield:

: 77844-50-9
(2S,3S,4R)-2-aminooctadecane-1,3,4-triol hydrochloride

: 1384424-10-5
1-O-(6-O-toluenesulfonyl-α-D-galactopyranosyl)-2-(11-(3,4-difluorophenyl)undecanoyl)amino-D-ribo-1,3,4-octadecanetriol

Guidance literature:: Multi-step reaction with 9 steps

1: triflic azide; potassium carbonate; copper(II) sulfate / methanol; dichloromethane; water / 12 h / 0 - 20 °C

2: triethylamine / toluene / 21 h / 50 - 55 °C

3: sodium hydride / N,N-dimethyl-formamide; toluene / 18 h / 50 - 60 °C

4: hydrogenchloride / methanol; water; toluene / 20 h / 50 - 60 °C

5: Dimethyldisulphide; trifluoromethylsulfonic anhydride / tetrahydrofuran / 0.33 h / -10 °C / Molecular sieve

6: lithium aluminium tetrahydride / tetrahydrofuran / 1.17 h / 0 - 20 °C

7: 4-methyl-morpholine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane / 12 h / 20 °C

8: hydrogen; palladium(II) hydroxide / methanol; dichloromethane / 12 h / 20 °C

9: pyridine / 16 h / 0 - 20 °C

With 4-methyl-morpholine; pyridine; hydrogenchloride; lithium aluminium tetrahydride; Dimethyldisulphide; trifluoromethylsulfonic anhydride; triflic azide; hydrogen; palladium(II) hydroxide; sodium hydride; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; copper(II) sulfate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1002/cbic.201200004