N-2-[N'-(N^α-benzyloxycarbonyl,N^ε-tert-butyloxycarbonyl-L-Lys-N^ε-tert-butyloxycarbonyl-L-Lys)]aminoethyl-N,N-di-n-tetradecylamine

Base Information

• Chemical Name: N-2-[N'-(N^α-benzyloxycarbonyl,N^ε-tert-butyloxycarbonyl-L-Lys-N^ε-tert-butyloxycarbonyl-L-Lys)]aminoethyl-N,N-di-n-tetradecylamine
• CAS No.: 678975-70-7
• Molecular Formula: C₆₀H₁₁₀N₆O₈
• Molecular Weight: 1043.57

Synonyms:N-2-[N'-(N^α-benzyloxycarbonyl,N^ε-tert-butyloxycarbonyl-L-Lys-N^ε-tert-butyloxycarbonyl-L-Lys)]aminoethyl-N,N-di-n-tetradecylamine

Chemical Property of N-2-[N'-(N^α-benzyloxycarbonyl,N^ε-tert-butyloxycarbonyl-L-Lys-N^ε-tert-butyloxycarbonyl-L-Lys)]aminoethyl-N,N-di-n-tetradecylamine

Chemical Property:

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Technology Process of N-2-[N'-(N^α-benzyloxycarbonyl,N^ε-tert-butyloxycarbonyl-L-Lys-N^ε-tert-butyloxycarbonyl-L-Lys)]aminoethyl-N,N-di-n-tetradecylamine

There total 3 articles about N-2-[N'-(N^α-benzyloxycarbonyl,N^ε-tert-butyloxycarbonyl-L-Lys-N^ε-tert-butyloxycarbonyl-L-Lys)]aminoethyl-N,N-di-n-tetradecylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Z-Lys(Boc)-OH (2389-60-8) → N-2-[N'-(Nα-benzyloxycarbonyl,Nε-tert-butyloxycarbonyl-L-Lys-Nε-tert-butyloxycarbonyl-L-Lys)]aminoethyl-N,N-di-n-tetradecylamine (678975-70-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: N-hydroxysuccinimide; dicyclohexylcarbodiimide / CH₂Cl₂; dimethylformamide / 0.5 h

1.2: 76.8 percent / 4-(dimethylamino)pyridine / CH₂Cl₂; dimethylformamide / 24 h / 20 °C

2.1: 83.8 percent / ammonium formate; glacial acetic acid / Pd/C / methanol / 4 h

3.1: N-hydroxysuccinimide; dicyclohexylcarbodiimide / CH₂Cl₂; dimethylformamide / 0.5 h

3.2: 77.9 percent / 4-(dimethylamino)pyridine / CH₂Cl₂; dimethylformamide / 24 h / 20 °C

With 1-hydroxy-pyrrolidine-2,5-dione; ammonium formate; acetic acid; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm030541+

Reference yield:

N-aminoethyl-N,N-di-n-tetradecylamine → N-2-[N'-(Nα-benzyloxycarbonyl,Nε-tert-butyloxycarbonyl-L-Lys-Nε-tert-butyloxycarbonyl-L-Lys)]aminoethyl-N,N-di-n-tetradecylamine (678975-70-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: N-hydroxysuccinimide; dicyclohexylcarbodiimide / CH₂Cl₂; dimethylformamide / 0.5 h

1.2: 76.8 percent / 4-(dimethylamino)pyridine / CH₂Cl₂; dimethylformamide / 24 h / 20 °C

2.1: 83.8 percent / ammonium formate; glacial acetic acid / Pd/C / methanol / 4 h

3.1: N-hydroxysuccinimide; dicyclohexylcarbodiimide / CH₂Cl₂; dimethylformamide / 0.5 h

3.2: 77.9 percent / 4-(dimethylamino)pyridine / CH₂Cl₂; dimethylformamide / 24 h / 20 °C

With 1-hydroxy-pyrrolidine-2,5-dione; ammonium formate; acetic acid; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm030541+

Reference yield:

N-2-[N'-(Nα-benzyloxycarbonyl-Nε-t-butyloxycarbonyl-L-Lysyl)]aminoethyl-N,N-di-n-tetradecylamine (678975-64-9) → N-2-[N'-(Nα-benzyloxycarbonyl,Nε-tert-butyloxycarbonyl-L-Lys-Nε-tert-butyloxycarbonyl-L-Lys)]aminoethyl-N,N-di-n-tetradecylamine (678975-70-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 83.8 percent / ammonium formate; glacial acetic acid / Pd/C / methanol / 4 h

2.1: N-hydroxysuccinimide; dicyclohexylcarbodiimide / CH₂Cl₂; dimethylformamide / 0.5 h

2.2: 77.9 percent / 4-(dimethylamino)pyridine / CH₂Cl₂; dimethylformamide / 24 h / 20 °C

With 1-hydroxy-pyrrolidine-2,5-dione; ammonium formate; acetic acid; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm030541+

upstream raw materials:

Z-Lys(Boc)-OH

N-2-[N'-(N^α-benzyloxycarbonyl-N^ε-t-butyloxycarbonyl-L-Lysyl)]aminoethyl-N,N-di-n-tetradecylamine

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