3-(4-Hydroxy-4-phenyl-piperidin-1-ylmethyl)-3,4-dihydro-2H-naphthalen-1-one

Base Information

Chemical Name:3-(4-Hydroxy-4-phenyl-piperidin-1-ylmethyl)-3,4-dihydro-2H-naphthalen-1-one
CAS No.:133496-59-0
Molecular Formula:C₂₂H₂₅NO₂
Molecular Weight:335.446
Hs Code.:

Synonyms:3-(4-Hydroxy-4-phenyl-piperidin-1-ylmethyl)-3,4-dihydro-2H-naphthalen-1-one

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Chemical Property of 3-(4-Hydroxy-4-phenyl-piperidin-1-ylmethyl)-3,4-dihydro-2H-naphthalen-1-one

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Technology Process of 3-(4-Hydroxy-4-phenyl-piperidin-1-ylmethyl)-3,4-dihydro-2H-naphthalen-1-one

There total 4 articles about 3-(4-Hydroxy-4-phenyl-piperidin-1-ylmethyl)-3,4-dihydro-2H-naphthalen-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 133496-55-6
3-Benzyl-4-(4-hydroxy-4-phenyl-piperidin-1-yl)-butyric acid methyl ester

: 133496-59-0
3-(4-Hydroxy-4-phenyl-piperidin-1-ylmethyl)-3,4-dihydro-2H-naphthalen-1-one

Guidance literature:: With PPA; at 130 ℃; for 5h;
DOI:10.1021/jm00111a046

Reference yield:

: 40807-61-2
4-hydroxy-4-phenylpiperidin

: 133496-59-0
3-(4-Hydroxy-4-phenyl-piperidin-1-ylmethyl)-3,4-dihydro-2H-naphthalen-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: 53 percent / Na₂CO₃, KI / various solvent(s) / 20 h / Heating

2: 33 percent / polyphosphoric acid / 5 h / 130 °C

With PPA; sodium carbonate; potassium iodide; In various solvent(s);
DOI:10.1021/jm00111a046

Reference yield:

: 133496-51-2
β-(bromomethyl)-γ-phenylbutyric acid

: 133496-59-0
3-(4-Hydroxy-4-phenyl-piperidin-1-ylmethyl)-3,4-dihydro-2H-naphthalen-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: diethyl ether

2: 53 percent / Na₂CO₃, KI / various solvent(s) / 20 h / Heating

3: 33 percent / polyphosphoric acid / 5 h / 130 °C

With PPA; sodium carbonate; potassium iodide; In diethyl ether;
DOI:10.1021/jm00111a046