Gltptpat amide

Base Information

• Chemical Name: Gltptpat amide
• CAS No.: 93240-39-2
• Molecular Formula: C₄₈H₆₅N₁₁O₁₂
• Molecular Weight: 988.111
• Mol file: 93240-39-2.mol

Synonyms:GLTPTPAT amide;Glu-Leu-Thr-Phe-Thr-Pro-Asn-Trp-NH2;glutamyl-leucyl-threonyl-phenylalanyl-threonyl-prolyl-asparaginyl-tryptophanamide;hypertrehalosemic hormone II;hypertrehalosemic peptide II

Chemical Property of Gltptpat amide

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 1528.1°C at 760 mmHg
• PKA: 13.18±0.20(Predicted)
• Flash Point: 878°C
• PSA: 366.44000
• Density: 1.35g/cm³
• LogP: 1.31260
• XLogP3: -1
• Hydrogen Bond Donor Count: 12
• Hydrogen Bond Acceptor Count: 12
• Rotatable Bond Count: 24
• Exact Mass: 987.48141655
• Heavy Atom Count: 71
• Complexity: 1950

Purity/Quality:

MYOACTIVE PEPTIDE II-COCKROACH 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC(C)C(C(=O)NC(C(C)O)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(C(C)O)C(=O)N2CCCC2C(=O)NC(CC(=O)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N)NC(=O)C5CCC(=O)N5
• Isomeric SMILES: CCC(C)[C@@H](C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N2CCCC2C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC3=CNC4=CC=CC=C43)C(=O)N)NC(=O)C5CCC(=O)N5

Technology Process of Gltptpat amide

There total 15 articles about Gltptpat amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-tert-butoxycarbonyl-L-leucine (13139-15-6,53296-34-7) → periplanetin CC-2 (93240-39-2)

Guidance literature:

Multi-step reaction with 6 steps

1: 74 percent / dicyclohexylcarbodiimide (DCC), N-hydroxysuccinimide (HO-Su), Triethylamine (TEA) / CH₂Cl₂

2: 89 percent / 1 N aq. HCl / dioxane / 0.5 h / Ambient temperature

3: triethylamine (TEA) / CHCl₃

4: 2 g / H₂, 5percent aq. CH₃COOH / 10percent Pd/BaSO₄ / methanol

5: 30 percent / hydrazine hydrate / methanol / 5 h / 4 °C

6: 1.) amyl nitrite, 4 N aq. HCl / 1.) dioxane, 2.) DMF, dioxane

With hydrogenchloride; 1-hydroxy-pyrrolidine-2,5-dione; n-Amyl nitrite; hydrogen; hydrazine hydrate; acetic acid; triethylamine; dicyclohexyl-carbodiimide; Pd-BaSO₄; In 1,4-dioxane; methanol; dichloromethane; chloroform;

Reference yield:

Cbz-L-pGlu-OH (32159-21-0) → periplanetin CC-2 (93240-39-2)

Guidance literature:

Multi-step reaction with 5 steps

1: triethylamine (TEA) / CHCl₃

2: triethylamine (TEA) / CHCl₃

3: 2 g / H₂, 5percent aq. CH₃COOH / 10percent Pd/BaSO₄ / methanol

4: 30 percent / hydrazine hydrate / methanol / 5 h / 4 °C

5: 1.) amyl nitrite, 4 N aq. HCl / 1.) dioxane, 2.) DMF, dioxane

With hydrogenchloride; n-Amyl nitrite; hydrogen; hydrazine hydrate; acetic acid; triethylamine; Pd-BaSO₄; In methanol; chloroform;

Reference yield:

(S)-2-Ethoxycarbonyloxycarbonyl-5-oxo-pyrrolidine-1-carboxylic acid benzyl ester (82379-40-6) → periplanetin CC-2 (93240-39-2)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine (TEA) / CHCl₃

2: 2 g / H₂, 5percent aq. CH₃COOH / 10percent Pd/BaSO₄ / methanol

3: 30 percent / hydrazine hydrate / methanol / 5 h / 4 °C

4: 1.) amyl nitrite, 4 N aq. HCl / 1.) dioxane, 2.) DMF, dioxane

With hydrogenchloride; n-Amyl nitrite; hydrogen; hydrazine hydrate; acetic acid; triethylamine; Pd-BaSO₄; In methanol; chloroform;

upstream raw materials:

(S)-5-Oxo-pyrrolidine-2-carboxylic acid {(S)-1-[(1S,2R)-1-((S)-1-hydrazinocarbonyl-2-phenyl-ethylcarbamoyl)-2-hydroxy-propylcarbamoyl]-3-methyl-butyl}-amide

(S)-2-{[(S)-1-((2S,3R)-2-Amino-3-hydroxy-butyryl)-pyrrolidine-2-carbonyl]-amino}-N¹-[(S)-1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-succinamide

N-tert-butoxycarbonyl-L-leucine

Cbz-L-pGlu-OH