2-amino-3,4-bis(aminocarbonyl)-1-<(S)-2,4-O-benzylidene-2,4-dihydroxybutyl>pyrrole

Base Information

• Chemical Name: 2-amino-3,4-bis(aminocarbonyl)-1-<(S)-2,4-O-benzylidene-2,4-dihydroxybutyl>pyrrole
• CAS No.: 127945-38-4
• Molecular Formula: C₁₇H₂₀N₄O₄
• Molecular Weight: 344.37

Synonyms:2-amino-3,4-bis(aminocarbonyl)-1-<(S)-2,4-O-benzylidene-2,4-dihydroxybutyl>pyrrole

Chemical Property of 2-amino-3,4-bis(aminocarbonyl)-1-<(S)-2,4-O-benzylidene-2,4-dihydroxybutyl>pyrrole

Chemical Property:

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Technology Process of 2-amino-3,4-bis(aminocarbonyl)-1-<(S)-2,4-O-benzylidene-2,4-dihydroxybutyl>pyrrole

There total 2 articles about 2-amino-3,4-bis(aminocarbonyl)-1-<(S)-2,4-O-benzylidene-2,4-dihydroxybutyl>pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

2-amino-3,4-bis(aminocarbonyl)-5-(methylthio)-1-<(S)-2,4-O-benzylidene-2,4-dihydroxybutyl>pyrrole (127945-34-0) → 2-amino-3,4-bis(aminocarbonyl)-1-<(S)-2,4-O-benzylidene-2,4-dihydroxybutyl>pyrrole (127945-38-4)

Guidance literature:

With nickel; In ethanol; for 18h; Heating;

DOI:10.1021/jm00170a019

Reference yield:

2-amino-3,4-bis(aminocarbonyl)-5-(methylthio)pyrrole (38187-09-6) → 2-amino-3,4-bis(aminocarbonyl)-1-<(S)-2,4-O-benzylidene-2,4-dihydroxybutyl>pyrrole (127945-38-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaH / 1.) DMF, RT, 5 min, 2.) 100 deg C, 18 h

2: 54 percent / Raney Ni / ethanol / 18 h / Heating

With nickel; sodium hydride; In ethanol;

DOI:10.1021/jm00170a019

Reference yield: 42.0%

2-amino-3,4-bis(aminocarbonyl)-1-<(S)-2,4-O-benzylidene-2,4-dihydroxybutyl>pyrrole (127945-38-4) → 2-amino-3,4-dicyano-1-<(S)-2,4-O-benzylidene-2,4-dihydroxybutyl>pyrrole (127945-46-4)

Guidance literature:

With pyridine; p-toluenesulfonyl chloride; for 24h; Ambient temperature;

DOI:10.1021/jm00170a019

upstream raw materials:

2-amino-3,4-bis(aminocarbonyl)-5-(methylthio)-1-<(S)-2,4-O-benzylidene-2,4-dihydroxybutyl>pyrrole

2-amino-3,4-bis(aminocarbonyl)-5-(methylthio)pyrrole

Downstream raw materials:

2-amino-5-(aminocarbonyl)-7-<(S)-2,4-O-benzylidene-2,4-dihydroxybutyl>pyrrolo<2,3-d>pyrimidin-4-one

2-amino-3,4-dicyano-1-<(S)-2,4-O-benzylidene-2,4-dihydroxybutyl>pyrrole

2-amino-5-cyano-7-<(S)-2,4-dihydroxybutyl>pyrrolo<2,3-d>pyrimidin-4-one

2-amino-5-(aminocarbonyl)-7-<(S)-2,4-dihydroxybutyl>pyrrolo<2,3-d>pyrimidin-4-one

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