2-(2-(2-oxo-2H-chromen-4-yloxy)acetyl)-N-phenylhydrazinecarbothioamide

Base Information

• Chemical Name: 2-(2-(2-oxo-2H-chromen-4-yloxy)acetyl)-N-phenylhydrazinecarbothioamide
• CAS No.: 1392012-53-1
• Molecular Formula: C₁₈H₁₅N₃O₄S
• Molecular Weight: 369.401
• Mol file: 1392012-53-1.mol

Synonyms:2-(2-(2-oxo-2H-chromen-4-yloxy)acetyl)-N-phenylhydrazinecarbothioamide

Chemical Property of 2-(2-(2-oxo-2H-chromen-4-yloxy)acetyl)-N-phenylhydrazinecarbothioamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-(2-oxo-2H-chromen-4-yloxy)acetyl)-N-phenylhydrazinecarbothioamide

There total 3 articles about 2-(2-(2-oxo-2H-chromen-4-yloxy)acetyl)-N-phenylhydrazinecarbothioamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-(2-oxo-2H-chromen-4-yloxy)acetohydrazide (669768-99-4) + phenyl isothiocyanate (103-72-0) → 2-(2-(2-oxo-2H-chromen-4-yloxy)acetyl)-N-phenylhydrazinecarbothioamide (1392012-53-1)

Guidance literature:

In ethanol; for 12h; Reflux;

DOI:10.3390/molecules17055713

Reference yield:

4-hydroxy[1]benzopyran-2-one (1076-38-6,92395-12-5) → 2-(2-(2-oxo-2H-chromen-4-yloxy)acetyl)-N-phenylhydrazinecarbothioamide (1392012-53-1)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / acetone / 12 h / Reflux

2: hydrazine hydrate / ethanol / 4 h / Reflux

3: ethanol / 12 h / Reflux

With potassium carbonate; hydrazine hydrate; In ethanol; acetone;

DOI:10.3390/molecules17055713

Reference yield:

ethyl 2-[(2-oxo-2H-chromen-4-yl)oxy]acetate (462094-44-6) → 2-(2-(2-oxo-2H-chromen-4-yloxy)acetyl)-N-phenylhydrazinecarbothioamide (1392012-53-1)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / 4 h / Reflux

2: ethanol / 12 h / Reflux

With hydrazine hydrate; In ethanol;

DOI:10.3390/molecules17055713

upstream raw materials:

4-hydroxy[1]benzopyran-2-one

2-(2-oxo-2H-chromen-4-yloxy)acetohydrazide

phenyl isothiocyanate

ethyl 2-[(2-oxo-2H-chromen-4-yl)oxy]acetate

Downstream raw materials:

4-((5-mercapto-4-phenyl-4H-1,2,4-triazol-3-yl)methoxy)-2H-chromen-2-one

4-((5-(phenylamino)-1,3,4-thiadiazol-2-yl)methoxy)-2H-chromen-2-one