(S)-3-((S)-1-(4-bromophenyl)ethyl)-6-(4-fluorophenyl)-6-(3-hydroxy-2-oxopropyl)-1,3-oxazinan-2-one

Base Information

Chemical Name:(S)-3-((S)-1-(4-bromophenyl)ethyl)-6-(4-fluorophenyl)-6-(3-hydroxy-2-oxopropyl)-1,3-oxazinan-2-one
CAS No.:1114559-75-9
Molecular Formula:C₂₁H₂₁BrFNO₄
Molecular Weight:450.304
Hs Code.:

Synonyms:(S)-3-((S)-1-(4-bromophenyl)ethyl)-6-(4-fluorophenyl)-6-(3-hydroxy-2-oxopropyl)-1,3-oxazinan-2-one

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Chemical Property of (S)-3-((S)-1-(4-bromophenyl)ethyl)-6-(4-fluorophenyl)-6-(3-hydroxy-2-oxopropyl)-1,3-oxazinan-2-one

Chemical Property:

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Technology Process of (S)-3-((S)-1-(4-bromophenyl)ethyl)-6-(4-fluorophenyl)-6-(3-hydroxy-2-oxopropyl)-1,3-oxazinan-2-one

There total 2 articles about (S)-3-((S)-1-(4-bromophenyl)ethyl)-6-(4-fluorophenyl)-6-(3-hydroxy-2-oxopropyl)-1,3-oxazinan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1114559-73-7
(6S)-3-((S)-1-(4-bromophenyl)ethyl)-6-(2,3-dihydroxypropyl)-6-(4-fluorophenyl)-1,3-oxazinan-2-one

: 1114559-23-7
2-((S)-3-((S)-1-(4-bromophenyl)ethyl)-6-(4-fluorophenyl)-2-oxo-1,3-oxazinan-6-yl)acetic acid

: 1114559-75-9
(S)-3-((S)-1-(4-bromophenyl)ethyl)-6-(4-fluorophenyl)-6-(3-hydroxy-2-oxopropyl)-1,3-oxazinan-2-one

Guidance literature:: With Oxone; rhodium(III) chloride hydrate; sodium hydrogencarbonate; In water; ethyl acetate; acetonitrile; at 20 ℃; for 1h;
DOI:10.1016/j.bmc.2017.04.033

Reference yield:

: 1110641-77-4
(R)-6-allyl-3-((S)-1-(4-bromophenyl)ethyl)-6-(4-fluorophenyl)-1,3-oxazinan-2-one

: 1114559-75-9
(S)-3-((S)-1-(4-bromophenyl)ethyl)-6-(4-fluorophenyl)-6-(3-hydroxy-2-oxopropyl)-1,3-oxazinan-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / dichloromethane; tert-butyl alcohol / 20 °C

2: Oxone; sodium hydrogencarbonate; rhodium(III) chloride hydrate / ethyl acetate; water; acetonitrile / 1 h / 20 °C

With Oxone; osmium(VIII) oxide; rhodium(III) chloride hydrate; sodium hydrogencarbonate; 4-methylmorpholine N-oxide; In dichloromethane; water; ethyl acetate; acetonitrile; tert-butyl alcohol;
DOI:10.1016/j.bmc.2017.04.033