5-benzyloxy-6-hydroxy-2-(1-phenylcyclopentylmethyl)pyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl]cyclopropylmethylamide

Base Information

Chemical Name:5-benzyloxy-6-hydroxy-2-(1-phenylcyclopentylmethyl)pyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl]cyclopropylmethylamide
CAS No.:1616924-72-1
Molecular Formula:C₃₆H₄₉N₃O₄Si
Molecular Weight:615.888
Hs Code.:

5-benzyloxy-6-hydroxy-2-(1-phenylcyclopentylmethyl)pyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl]cyclopropylmethylamide

Synonyms:5-benzyloxy-6-hydroxy-2-(1-phenylcyclopentylmethyl)pyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl]cyclopropylmethylamide

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Chemical Property of 5-benzyloxy-6-hydroxy-2-(1-phenylcyclopentylmethyl)pyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl]cyclopropylmethylamide

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Technology Process of 5-benzyloxy-6-hydroxy-2-(1-phenylcyclopentylmethyl)pyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl]cyclopropylmethylamide

There total 11 articles about 5-benzyloxy-6-hydroxy-2-(1-phenylcyclopentylmethyl)pyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl]cyclopropylmethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.82%

: 1616922-83-8
5-(benzyloxy)-6-hydroxy-2-((1-phenylcyclopentyl)methyl)pyrimidine-4-carboxylic acid

: 532407-13-9
[2-(tert-butyldimethylsilanyloxy)ethyl]cyclopropylmethylamine

: 1616924-72-1
5-benzyloxy-6-hydroxy-2-(1-phenylcyclopentylmethyl)pyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl]cyclopropylmethylamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 20h;

Reference yield:

: 77-57-6
1-phenyl-1-cyclopentanecarbonitrile

: 1616924-72-1
5-benzyloxy-6-hydroxy-2-(1-phenylcyclopentylmethyl)pyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl]cyclopropylmethylamide

Guidance literature:: Multi-step reaction with 8 steps

1: diisobutylaluminium hydride / toluene; dichloromethane / 2 h / -78 °C

2: sodium tetrahydroborate; methanol / 2 h / 0 - 20 °C

3: triethylamine / dichloromethane / 16 h / 0 - 20 °C

4: potassium iodide / dimethyl sulfoxide / 20 h / 20 - 140 °C

5: ammonium chloride; trimethylaluminum / toluene / 14 h / 5 - 80 °C

6: sodium methylate / methanol / 16 h / 0 - 20 °C

7: lithium hydroxide monohydrate / tetrahydrofuran; water / 18 h / Reflux

8: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 h / 20 °C

With methanol; sodium tetrahydroborate; lithium hydroxide monohydrate; trimethylaluminum; sodium methylate; diisobutylaluminium hydride; ammonium chloride; triethylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; potassium iodide; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;

Reference yield:

: 140-29-4
phenylacetonitrile

: 1616924-72-1
5-benzyloxy-6-hydroxy-2-(1-phenylcyclopentylmethyl)pyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl]cyclopropylmethylamide

Guidance literature:: Multi-step reaction with 9 steps

1: sodium hydride / diethyl ether; dimethyl sulfoxide / 3 h / 20 °C

2: diisobutylaluminium hydride / toluene; dichloromethane / 2 h / -78 °C

3: sodium tetrahydroborate; methanol / 2 h / 0 - 20 °C

4: triethylamine / dichloromethane / 16 h / 0 - 20 °C

5: potassium iodide / dimethyl sulfoxide / 20 h / 20 - 140 °C

6: ammonium chloride; trimethylaluminum / toluene / 14 h / 5 - 80 °C

7: sodium methylate / methanol / 16 h / 0 - 20 °C

8: lithium hydroxide monohydrate / tetrahydrofuran; water / 18 h / Reflux

9: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 h / 20 °C

With methanol; sodium tetrahydroborate; lithium hydroxide monohydrate; trimethylaluminum; sodium methylate; sodium hydride; diisobutylaluminium hydride; ammonium chloride; triethylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; potassium iodide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;