(R)-3-(3,4-dichloro-phenyl)-N-((S)-1-phenyl-ethyl)-3-[4-(1H-pyrazol-4-yl)-phenyl]-propionamide

Base Information

Chemical Name:(R)-3-(3,4-dichloro-phenyl)-N-((S)-1-phenyl-ethyl)-3-[4-(1H-pyrazol-4-yl)-phenyl]-propionamide
CAS No.:917899-04-8
Molecular Formula:C₂₆H₂₃Cl₂N₃O
Molecular Weight:464.394
Hs Code.:

Synonyms:(R)-3-(3,4-dichloro-phenyl)-N-((S)-1-phenyl-ethyl)-3-[4-(1H-pyrazol-4-yl)-phenyl]-propionamide

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Chemical Property of (R)-3-(3,4-dichloro-phenyl)-N-((S)-1-phenyl-ethyl)-3-[4-(1H-pyrazol-4-yl)-phenyl]-propionamide

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Technology Process of (R)-3-(3,4-dichloro-phenyl)-N-((S)-1-phenyl-ethyl)-3-[4-(1H-pyrazol-4-yl)-phenyl]-propionamide

There total 5 articles about (R)-3-(3,4-dichloro-phenyl)-N-((S)-1-phenyl-ethyl)-3-[4-(1H-pyrazol-4-yl)-phenyl]-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

: 917899-03-7
3-(3,4-dichloro-phenyl)-3-[4-(1H-pyrazol-4-yl)-phenyl]-propionic acid

: 2627-86-3
(S)-1-phenyl-ethylamine

: 917899-04-8
(R)-3-(3,4-dichloro-phenyl)-N-((S)-1-phenyl-ethyl)-3-[4-(1H-pyrazol-4-yl)-phenyl]-propionamide

Guidance literature:: 3-(3,4-dichloro-phenyl)-3-[4-(1H-pyrazol-4-yl)-phenyl]-propionic acid; With thionyl chloride; at 80 ℃; for 2h;

(S)-1-phenyl-ethylamine; With triethylamine; In dichloromethane; at 0 ℃; for 18h;

Reference yield:

: 917899-01-5
3-(4-bromo-phenyl)-3-(3,4-dichlorophenyl)-2-cyano-propionic acid ethyl ester

: 917899-04-8
(R)-3-(3,4-dichloro-phenyl)-N-((S)-1-phenyl-ethyl)-3-[4-(1H-pyrazol-4-yl)-phenyl]-propionamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sulfuric acid; water; acetic acid / 2 h / Heating / reflux

2.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / methanol; ethanol; water; toluene / 40 h / 95 °C

3.1: thionyl chloride / 2 h / 80 °C

3.2: 18 h / 0 °C

With potassium phosphate; thionyl chloride; sulfuric acid; water; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; ethanol; water; toluene;

Reference yield:

: 917899-02-6
3-(4-bromo-phenyl)-3-(3,4-dichlorophenyl)-propionic acid

: 917899-04-8
(R)-3-(3,4-dichloro-phenyl)-N-((S)-1-phenyl-ethyl)-3-[4-(1H-pyrazol-4-yl)-phenyl]-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / methanol; ethanol; water; toluene / 40 h / 95 °C

2.1: thionyl chloride / 2 h / 80 °C

2.2: 18 h / 0 °C

With potassium phosphate; thionyl chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; ethanol; water; toluene;