Technology Process of 1-(2-bromobenzyl)-3-isopropylindoline
There total 2 articles about 1-(2-bromobenzyl)-3-isopropylindoline which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: piperidine / ethanol / 2.5 h / Inert atmosphere; Reflux
2.1: palladium on carbon; hydrogen / methanol; dichloromethane / 4 h
3.1: dimethylsulfide borane complex / tetrahydrofuran / 16 h / 0 - 20 °C / Inert atmosphere
4.1: potassium carbonate; potassium iodide / acetonitrile / 1 h / 20 °C / Inert atmosphere
4.2: 12 h / Inert atmosphere
With
piperidine; dimethylsulfide borane complex; palladium on carbon; hydrogen; potassium carbonate; potassium iodide;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; acetonitrile;
DOI:10.1039/c1ob05527e
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: palladium on carbon; hydrogen / methanol; dichloromethane / 4 h
2.1: dimethylsulfide borane complex / tetrahydrofuran / 16 h / 0 - 20 °C / Inert atmosphere
3.1: potassium carbonate; potassium iodide / acetonitrile / 1 h / 20 °C / Inert atmosphere
3.2: 12 h / Inert atmosphere
With
dimethylsulfide borane complex; palladium on carbon; hydrogen; potassium carbonate; potassium iodide;
In
tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1039/c1ob05527e
- Guidance literature:
-
With
tri-n-butyl-tin hydride; 1,1'-azobis(1-cyanocyclohexanenitrile);
In
toluene;
for 18h;
Inert atmosphere;
Reflux;
DOI:10.1039/c1ob05527e
