(4R)-3-benzyl-4-[(2R)-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl](hydroxy)methyl]-1,3-oxazolidin-2-one

Base Information

Chemical Name:(4R)-3-benzyl-4-[(2R)-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl](hydroxy)methyl]-1,3-oxazolidin-2-one
CAS No.:80581-23-3
Molecular Formula:C₁₆H₂₁NO₅
Molecular Weight:307.346
Hs Code.:

Synonyms:(4R)-3-benzyl-4-[(2R)-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl](hydroxy)methyl]-1,3-oxazolidin-2-one

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Chemical Property of (4R)-3-benzyl-4-[(2R)-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl](hydroxy)methyl]-1,3-oxazolidin-2-one

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Technology Process of (4R)-3-benzyl-4-[(2R)-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl](hydroxy)methyl]-1,3-oxazolidin-2-one

There total 8 articles about (4R)-3-benzyl-4-[(2R)-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl](hydroxy)methyl]-1,3-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 318489-44-0
Benzyl-carbamic acid (2S,3R)-3-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-oxiranylmethyl ester

: 80581-23-3
(4R)-3-benzyl-4-[(2R)-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl](hydroxy)methyl]-1,3-oxazolidin-2-one

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; tert-butyl alcohol; at 0 ℃; for 2h;
DOI:10.1021/jo0012748

Reference yield:

: 79060-23-4
(2E)-3-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]prop-2-en-1-ol

: 80581-23-3
(4R)-3-benzyl-4-[(2R)-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl](hydroxy)methyl]-1,3-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 61 percent / t-BuOOH; Ti(Oi-Pr)4; diisopropyl L-(+)-tartrate / CH₂Cl₂ / -30 °C

2: 92 percent / (i-Pr)2NEt / benzene / 60 °C

3: 84 percent / potassium tert-butoxide / tetrahydrofuran; 2-methyl-propan-2-ol / 2 h / 0 °C

With titanium(IV) isopropylate; tert.-butylhydroperoxide; L-(+)-diisopropyl tartrate; potassium tert-butylate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; tert-butyl alcohol; benzene; 1: Sharpless asymmetric epoxidation;
DOI:10.1021/jo0012748

Reference yield:

: 64520-58-7,917877-01-1
ethyl (E)-3-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)acrylate

: 80581-23-3
(4R)-3-benzyl-4-[(2R)-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl](hydroxy)methyl]-1,3-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 89 percent / diisobutylaluminum hydride / CH₂Cl₂ / -78 °C

2: 61 percent / t-BuOOH; Ti(Oi-Pr)4; diisopropyl L-(+)-tartrate / CH₂Cl₂ / -30 °C

3: 92 percent / (i-Pr)2NEt / benzene / 60 °C

4: 84 percent / potassium tert-butoxide / tetrahydrofuran; 2-methyl-propan-2-ol / 2 h / 0 °C

With titanium(IV) isopropylate; tert.-butylhydroperoxide; L-(+)-diisopropyl tartrate; potassium tert-butylate; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; tert-butyl alcohol; benzene; 2: Sharpless asymmetric epoxidation;
DOI:10.1021/jo0012748