(E)-2-(2-Fluoro-phenyl)-3-[2-nitro-5-(thiophen-3-ylmethoxy)-phenyl]-acrylic acid

Base Information

Chemical Name:(E)-2-(2-Fluoro-phenyl)-3-[2-nitro-5-(thiophen-3-ylmethoxy)-phenyl]-acrylic acid
CAS No.:210109-66-3
Molecular Formula:C₂₀H₁₄FNO₅S
Molecular Weight:399.399
Hs Code.:

Synonyms:(E)-2-(2-Fluoro-phenyl)-3-[2-nitro-5-(thiophen-3-ylmethoxy)-phenyl]-acrylic acid

Suppliers and Price of (E)-2-(2-Fluoro-phenyl)-3-[2-nitro-5-(thiophen-3-ylmethoxy)-phenyl]-acrylic acid

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Chemical Property of (E)-2-(2-Fluoro-phenyl)-3-[2-nitro-5-(thiophen-3-ylmethoxy)-phenyl]-acrylic acid

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Technology Process of (E)-2-(2-Fluoro-phenyl)-3-[2-nitro-5-(thiophen-3-ylmethoxy)-phenyl]-acrylic acid

There total 3 articles about (E)-2-(2-Fluoro-phenyl)-3-[2-nitro-5-(thiophen-3-ylmethoxy)-phenyl]-acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2746-23-8
3-(chloromethyl)thiophene

: 210109-66-3
(E)-2-(2-Fluoro-phenyl)-3-[2-nitro-5-(thiophen-3-ylmethoxy)-phenyl]-acrylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) t-BuOK / 1.) DMF, RT, 15 min, 2.) DMF, RT, 6 h

2: Ac₂O, Et₃N / 0.33 h / Heating

With potassium tert-butylate; acetic anhydride; triethylamine;
DOI:10.1021/jm970847e

Reference yield:

: 42454-06-8
2-nitro-5-hydroxybenzaldehyde

: 210109-66-3
(E)-2-(2-Fluoro-phenyl)-3-[2-nitro-5-(thiophen-3-ylmethoxy)-phenyl]-acrylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) t-BuOK / 1.) DMF, RT, 15 min, 2.) DMF, RT, 6 h

2: Ac₂O, Et₃N / 0.33 h / Heating

With potassium tert-butylate; acetic anhydride; triethylamine;
DOI:10.1021/jm970847e