Phenylmethyl -3-(5-hydroxy-2-pyridinyl)-2-oxo-5,6-diphenyl-4-morpholinecarboxylate

Base Information

Chemical Name:Phenylmethyl -3-(5-hydroxy-2-pyridinyl)-2-oxo-5,6-diphenyl-4-morpholinecarboxylate
CAS No.:159150-97-7
Molecular Formula:C₃₀H₂₆N₂O₅
Molecular Weight:494.547
Hs Code.:

Phenylmethyl <S-(3α,5β,6β)>-3-(5-hydroxy-2-pyridinyl)-2-oxo-5,6-diphenyl-4-morpholinecarboxylate

Synonyms:Phenylmethyl -3-(5-hydroxy-2-pyridinyl)-2-oxo-5,6-diphenyl-4-morpholinecarboxylate

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Chemical Property of Phenylmethyl -3-(5-hydroxy-2-pyridinyl)-2-oxo-5,6-diphenyl-4-morpholinecarboxylate

Chemical Property:

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Technology Process of Phenylmethyl -3-(5-hydroxy-2-pyridinyl)-2-oxo-5,6-diphenyl-4-morpholinecarboxylate

There total 4 articles about Phenylmethyl -3-(5-hydroxy-2-pyridinyl)-2-oxo-5,6-diphenyl-4-morpholinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 159150-96-6
Phenylmethyl -3-<5-<<(1,1-dimethylethyl)diphenylsilyl>oxy>-2-pyridinyl>-2-oxo-5,6-diphenyl-4-morpholinecarboxylate

: 159150-97-7
Phenylmethyl -3-(5-hydroxy-2-pyridinyl)-2-oxo-5,6-diphenyl-4-morpholinecarboxylate

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 0.25h; Ambient temperature;
DOI:10.1021/jo00101a056

Reference yield:

: 1121-78-4
5-Hydroxy-2-methylpyridine

: 159150-97-7
Phenylmethyl -3-(5-hydroxy-2-pyridinyl)-2-oxo-5,6-diphenyl-4-morpholinecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / imidazole / dimethylformamide / 12 h / Ambient temperature

2: 51 percent / NBS, AIBN / CCl₄ / 24 h / 50 °C

3: 60 percent / sodium bis(trimethylsilyl)amide / tetrahydrofuran / 1.) -100 deg C, 1 h, 2.) -78 deg C, 5 h

4: 79 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 0.25 h / Ambient temperature

With 1H-imidazole; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); tetrabutyl ammonium fluoride; sodium hexamethyldisilazane; In tetrahydrofuran; tetrachloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00101a056

Reference yield:

: 147936-65-0
5-<<(1,1-Dimethylethyl)diphenylsilyl>oxy>-2-methylpyridine

: 159150-97-7
Phenylmethyl -3-(5-hydroxy-2-pyridinyl)-2-oxo-5,6-diphenyl-4-morpholinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 51 percent / NBS, AIBN / CCl₄ / 24 h / 50 °C

2: 60 percent / sodium bis(trimethylsilyl)amide / tetrahydrofuran / 1.) -100 deg C, 1 h, 2.) -78 deg C, 5 h

3: 79 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 0.25 h / Ambient temperature

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); tetrabutyl ammonium fluoride; sodium hexamethyldisilazane; In tetrahydrofuran; tetrachloromethane;
DOI:10.1021/jo00101a056