3-(5-Chloro-2-fluorophenyl)propan-1-ol

Base Information

Chemical Name:3-(5-Chloro-2-fluorophenyl)propan-1-ol
CAS No.:135832-53-0
Molecular Formula:C₉H₁₀ClFO
Molecular Weight:188.629
Hs Code.:
DSSTox Substance ID:DTXSID401303029

Synonyms:3-(5-chloro-2-fluorophenyl)propan-1-ol;135832-53-0;SCHEMBL79525;5-Chloro-2-fluorobenzenepropanol;KXQLTZINLFWGPH-UHFFFAOYSA-N;DTXSID401303029;AKOS006311602;3-(5-chloro-2-fluorophenyl)-1-propanol;EN300-1625788

Suppliers and Price of 3-(5-Chloro-2-fluorophenyl)propan-1-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 3-(5-Chloro-2-fluorophenyl)propan-1-ol

Chemical Property:

XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:188.0404208
Heavy Atom Count:12
Complexity:132

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=C(C=C1Cl)CCCO)F

Technology Process of 3-(5-Chloro-2-fluorophenyl)propan-1-ol

There total 6 articles about 3-(5-Chloro-2-fluorophenyl)propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1093173-19-3
3-(5-chloro-2-fluorophenyl)-2-propyne-1-ol

: 135832-53-0
3-(5-chloro-2-fluorophenyl)propanol

Guidance literature:: With hydrogen; Wilkinson's catalyst; In toluene; at 60 ℃; for 11h;

Reference yield:

: 135832-52-9
3-(5-chloro-2-fluorophenyl)propionic acid

: 135832-53-0
3-(5-chloro-2-fluorophenyl)propanol

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; at 35 ℃; for 1h;
DOI:10.1021/jm00114a020

Reference yield:

: 452-66-4
5-chloro-2-fluorotoluene

: 135832-53-0
3-(5-chloro-2-fluorophenyl)propanol

Guidance literature:: Multi-step reaction with 5 steps

1: 13.92 g / N-bromosuccinimide, benzoyl peroxide / CCl₄ / 5 h / Heating

2: 1.) NaH / 1.) DMF, 60 deg C, 2 h, 2.) DMF, 60 deg C, 3.5 h

3: 6 N aq. HCl / Heating

4: 10percent aq. NaOH / 8 h / Heating

5: 1.57 g / LiAlH₄ / diethyl ether / 1 h / 35 °C

With hydrogenchloride; sodium hydroxide; N-Bromosuccinimide; lithium aluminium tetrahydride; Perbenzoic acid; sodium hydride; In tetrachloromethane; diethyl ether;
DOI:10.1021/jm00114a020