(R)-4-(2-(bis(4-(tert-butyl)phenyl)fluoromethyl)pyrrolidin-1-yl)-6,7-dihydro-5H-cyclopenta[b]pyridine

Base Information

• Chemical Name: (R)-4-(2-(bis(4-(tert-butyl)phenyl)fluoromethyl)pyrrolidin-1-yl)-6,7-dihydro-5H-cyclopenta[b]pyridine
• CAS No.: 1592000-35-5
• Molecular Formula: C₃₃H₄₁FN₂
• Molecular Weight: 484.7
• Mol file: 1592000-35-5.mol

Synonyms:(R)-4-(2-(bis(4-(tert-butyl)phenyl)fluoromethyl)pyrrolidin-1-yl)-6,7-dihydro-5H-cyclopenta[b]pyridine

Chemical Property of (R)-4-(2-(bis(4-(tert-butyl)phenyl)fluoromethyl)pyrrolidin-1-yl)-6,7-dihydro-5H-cyclopenta[b]pyridine

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of (R)-4-(2-(bis(4-(tert-butyl)phenyl)fluoromethyl)pyrrolidin-1-yl)-6,7-dihydro-5H-cyclopenta[b]pyridine

There total 2 articles about (R)-4-(2-(bis(4-(tert-butyl)phenyl)fluoromethyl)pyrrolidin-1-yl)-6,7-dihydro-5H-cyclopenta[b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

4-chloro-6,7-dihydro-5H-cyclopenta[b]pyridine (54664-55-0) + (S)-2-{bis[4-(tert-butyl)phenyl]fluoromethyl}pyrrolidine (1403755-27-0) → (R)-4-(2-(bis(4-(tert-butyl)phenyl)fluoromethyl)pyrrolidin-1-yl)-6,7-dihydro-5H-cyclopenta[b]pyridine (1592000-35-5)

Guidance literature:

With potassium tert-butylate; palladium diacetate; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride; In toluene; at 110 ℃; Inert atmosphere; Schlenk technique;

DOI:10.1002/ejoc.201301730

Reference yield:

4-chloro-6,7-dihydro-5H-cyclopenta[b]pyridine (54664-55-0) + (S)-2-{bis[4-(tert-butyl)phenyl]fluoromethyl}pyrrolidine (1403755-27-0) → (R)-4-(2-(bis(4-(tert-butyl)phenyl)fluoromethyl)pyrrolidin-1-yl)-6,7-dihydro-5H-cyclopenta[b]pyridine (1592000-35-5) + (R)-4-(2-(bis(4-(tert-butyl)phenyl)fluoromethyl)pyrrolidin-1-yl)-6,7-dihydro-5H-cyclopenta[b]pyridine

Guidance literature:

With potassium tert-butylate; palladium diacetate; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride; In toluene; at 110 ℃; Overall yield = 75 %; Overall yield = 500 mg; Schlenk technique; Inert atmosphere;

DOI:10.1002/ejoc.201301730

upstream raw materials:

4-chloro-6,7-dihydro-5H-cyclopenta[b]pyridine

(S)-2-{bis[4-(tert-butyl)phenyl]fluoromethyl}pyrrolidine