Technology Process of (Z)-4,5-dimethyl-6-(para-methoxybenzyloxy)-hex-4-enal
There total 11 articles about (Z)-4,5-dimethyl-6-(para-methoxybenzyloxy)-hex-4-enal which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: 1H-imidazole / N,N-dimethyl-formamide / 25 °C
2.1: n-butyllithium / tetrahydrofuran / -78 °C
3.1: copper(l) iodide / tetrahydrofuran / -45 °C
3.2: -45 - 0 °C
4.1: diisobutylaluminium hydride / dichloromethane / -78 °C
5.1: trifluorormethanesulfonic acid / dichloromethane; cyclohexane / 25 °C
6.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 80 °C
7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 25 °C
8.1: Dess-Martin periodane / dichloromethane / 25 °C
With
1H-imidazole; copper(l) iodide; n-butyllithium; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; trifluorormethanesulfonic acid; tetrabutyl ammonium fluoride; diisobutylaluminium hydride; Dess-Martin periodane;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; cyclohexane; N,N-dimethyl-formamide;
6.1: Negishi cross-coupling reaction / 8.1: Dess-Martin oxidation;
DOI:10.1016/j.tetlet.2011.01.093
- Guidance literature:
-
Multi-step reaction with 2 steps
1: tetrabutyl ammonium fluoride / tetrahydrofuran / 25 °C
2: Dess-Martin periodane / dichloromethane / 25 °C
With
tetrabutyl ammonium fluoride; Dess-Martin periodane;
In
tetrahydrofuran; dichloromethane;
2: Dess-Martin oxidation;
DOI:10.1016/j.tetlet.2011.01.093
