(E)-benzyl (4-amino-5-((5-(methylamino)-5-oxo-1-phenylpent-3-en-2-yl)amino)-5-oxopentyl)carbamate

Base Information

Chemical Name:(E)-benzyl (4-amino-5-((5-(methylamino)-5-oxo-1-phenylpent-3-en-2-yl)amino)-5-oxopentyl)carbamate
CAS No.:1424360-96-2
Molecular Formula:C₂₅H₃₂N₄O₄
Molecular Weight:452.553
Hs Code.:

Synonyms:(E)-benzyl (4-amino-5-((5-(methylamino)-5-oxo-1-phenylpent-3-en-2-yl)amino)-5-oxopentyl)carbamate

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Chemical Property of (E)-benzyl (4-amino-5-((5-(methylamino)-5-oxo-1-phenylpent-3-en-2-yl)amino)-5-oxopentyl)carbamate

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Technology Process of (E)-benzyl (4-amino-5-((5-(methylamino)-5-oxo-1-phenylpent-3-en-2-yl)amino)-5-oxopentyl)carbamate

There total 5 articles about (E)-benzyl (4-amino-5-((5-(methylamino)-5-oxo-1-phenylpent-3-en-2-yl)amino)-5-oxopentyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1424360-80-4
(E)-[4-(1-benzyl-3-methylcarbamoylallylcarbamoyl)-4-tert-butoxycarbonylaminobutylamino]acetic acid benzyl ester

: 1424360-96-2
(E)-benzyl (4-amino-5-((5-(methylamino)-5-oxo-1-phenylpent-3-en-2-yl)amino)-5-oxopentyl)carbamate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 36h;

Reference yield:

: 1424360-76-8
(E)-ethyl 4-(5-(((benzyloxy)carbonyl)amino)-2-((tert-butoxycarbonyl)amino)pentanamido)-5-phenylpent-2-enoate

: 1424360-96-2
(E)-benzyl (4-amino-5-((5-(methylamino)-5-oxo-1-phenylpent-3-en-2-yl)amino)-5-oxopentyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hydroxide; water / methanol; tetrahydrofuran / 36 h / 20 °C

2: triethylamine; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 4 h / 20 °C

3: trifluoroacetic acid / dichloromethane / 36 h / 20 °C

With dmap; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.bmcl.2012.12.100

Reference yield:

: 124818-94-6,116246-06-1
ethyl (2E,4S)-4-[(tert-butoxycarbonyl)amino]-5-phenylpent-2-enoate

: 1424360-96-2
(E)-benzyl (4-amino-5-((5-(methylamino)-5-oxo-1-phenylpent-3-en-2-yl)amino)-5-oxopentyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: trifluoroacetic acid / dichloromethane / 36 h / 20 °C

2: triethylamine; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 4 h / 20 °C

3: lithium hydroxide; water / methanol; tetrahydrofuran / 36 h / 20 °C

4: triethylamine; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 4 h / 20 °C

5: trifluoroacetic acid / dichloromethane / 36 h / 20 °C

With dmap; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.bmcl.2012.12.100