3-deoxy-3-(O,O-diethylphosphonothio)difluoromethyl-1,2-O-isopropylidene-5-O-(4-chlorobenzoyl)-α-D-ribofuranose

Base Information

Chemical Name:3-deoxy-3-(O,O-diethylphosphonothio)difluoromethyl-1,2-O-isopropylidene-5-O-(4-chlorobenzoyl)-α-D-ribofuranose
CAS No.:716357-07-2
Molecular Formula:C₂₀H₂₆ClF₂O₇PS
Molecular Weight:514.912
Hs Code.:

Synonyms:3-deoxy-3-(O,O-diethylphosphonothio)difluoromethyl-1,2-O-isopropylidene-5-O-(4-chlorobenzoyl)-α-D-ribofuranose

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Chemical Property of 3-deoxy-3-(O,O-diethylphosphonothio)difluoromethyl-1,2-O-isopropylidene-5-O-(4-chlorobenzoyl)-α-D-ribofuranose

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Technology Process of 3-deoxy-3-(O,O-diethylphosphonothio)difluoromethyl-1,2-O-isopropylidene-5-O-(4-chlorobenzoyl)-α-D-ribofuranose

There total 2 articles about 3-deoxy-3-(O,O-diethylphosphonothio)difluoromethyl-1,2-O-isopropylidene-5-O-(4-chlorobenzoyl)-α-D-ribofuranose which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 716357-05-0
3-(O,O-diethylphosphonothio)difluoromethyl-1,2-O-isopropylidene-5-O-(4-chlorobenzoyl)-α-D-allofuranose

: 716357-07-2
3-deoxy-3-(O,O-diethylphosphonothio)difluoromethyl-1,2-O-isopropylidene-5-O-(4-chlorobenzoyl)-α-D-ribofuranose

Guidance literature:: 3-(O,O-diethylphosphonothio)difluoromethyl-1,2-O-isopropylidene-5-O-(4-chlorobenzoyl)-α-D-allofuranose; With isopropylmagnesium chloride; In tetrahydrofuran; diethyl ether; at 0 ℃; for 1h;

With monomethyl oxalyl chloride; In tetrahydrofuran; diethyl ether; at 0 ℃; for 0.333333h;

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; for 2.33333h; Further stages.;
DOI:10.1016/j.tet.2004.03.082

Reference yield:

: 199787-15-0
5-O-(4-chlorobenzoyl)-1,2-O-isopropylidene-α-D-pentofuranose-3-urose

: 716357-07-2
3-deoxy-3-(O,O-diethylphosphonothio)difluoromethyl-1,2-O-isopropylidene-5-O-(4-chlorobenzoyl)-α-D-ribofuranose

Guidance literature:: Multi-step reaction with 2 steps

1.1: 72 percent / i-PrMgCl / tetrahydrofuran; diethyl ether / 5 h / -45 °C

2.1: i-PrMgCl / tetrahydrofuran; diethyl ether / 1 h / 0 °C

2.2: methyl oxalyl chloride / tetrahydrofuran; diethyl ether / 0.33 h / 0 °C

2.3: 64 percent / (n-Bu)3SnH; AIBN / toluene / 2.33 h

With isopropylmagnesium chloride; In tetrahydrofuran; diethyl ether;
DOI:10.1016/j.tet.2004.03.082