(1R,3aS,7aS)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-isopropyl-7a-(5-methyl-5-trimethylsilanyloxy-hexyloxymethyl)-octahydro-indene

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Chemical Name:(1R,3aS,7aS)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-isopropyl-7a-(5-methyl-5-trimethylsilanyloxy-hexyloxymethyl)-octahydro-indene
CAS No.:197647-52-2
Molecular Formula:C₄₄H₈₄O₄Si₃
Molecular Weight:761.405
Hs Code.:

(1R,3aS,7aS)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-isopropyl-7a-(5-methyl-5-trimethylsilanyloxy-hexyloxymethyl)-octahydro-indene

Synonyms:(1R,3aS,7aS)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-isopropyl-7a-(5-methyl-5-trimethylsilanyloxy-hexyloxymethyl)-octahydro-indene

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Chemical Property of (1R,3aS,7aS)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-isopropyl-7a-(5-methyl-5-trimethylsilanyloxy-hexyloxymethyl)-octahydro-indene

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Technology Process of (1R,3aS,7aS)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-isopropyl-7a-(5-methyl-5-trimethylsilanyloxy-hexyloxymethyl)-octahydro-indene

There total 9 articles about (1R,3aS,7aS)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-isopropyl-7a-(5-methyl-5-trimethylsilanyloxy-hexyloxymethyl)-octahydro-indene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 81522-68-1
[(2Z)-2-[(3S,5R)-3,5-bis(tert-butyldimethylsilanyloxy)-2-methylenecyclohexylidene]ethyl]diphenylphosphine oxide

: 197647-49-7
(1R,3aR,7aS)-1-Isopropyl-7a-(5-methyl-5-trimethylsilanyloxy-hexyloxymethyl)-octahydro-inden-4-one

: 197647-52-2
(1R,3aS,7aS)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-isopropyl-7a-(5-methyl-5-trimethylsilanyloxy-hexyloxymethyl)-octahydro-indene

Guidance literature:: DOI:10.1016/S0968-0896(98)00161-8

Reference yield:

: 66774-80-9,111924-49-3
(S)-2-((3R,3aR,7S,7aR)-octahydro-7-hydroxy-3a-methyl-1H-inden-3-yl)propyl 4-methylbenzenesulfonate

: 197647-52-2
(1R,3aS,7aS)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-isopropyl-7a-(5-methyl-5-trimethylsilanyloxy-hexyloxymethyl)-octahydro-indene

Guidance literature:: Multi-step reaction with 10 steps

1: 93 percent / LiAlH₄ / tetrahydrofuran / 21 h / Heating

2: 88 percent / lead tetraacetate, pyridine / benzene / 3.5 h / 15 °C / Irradiation

3: 39 percent / boron trifluoride etherate / -20 deg C, 45 min, room temperature, 1 h

4: 65 percent / potassium hydroxide / methanol / 2.5 h / Heating

5: 94 percent / imidazole / dimethylformamide / 4 h / Ambient temperature

6: 64 percent / potassium hydride, 18-crown-6 / tetrahydrofuran / 0.33 h / Ambient temperature

7: 79 percent / hydrofluoric acid / ethyl acetate; acetonitrile; H₂O / 0.67 h / Ambient temperature

8: 80 percent / pyridinium dichromate / CH₂Cl₂ / 18 h / Ambient temperature

9: 61 percent / N-ethyldiisopropylamine / CH₂Cl₂ / 2.33 h / Ambient temperature

10: 59 percent

With pyridine; 1H-imidazole; lead(IV) acetate; potassium hydroxide; lithium aluminium tetrahydride; dipyridinium dichromate; 18-crown-6 ether; boron trifluoride diethyl etherate; hydrogen fluoride; potassium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1016/S0968-0896(98)00161-8

Reference yield:

: 197647-61-3
20-methyl-de-A,B-pregnan-(8S)-ol

: 197647-52-2
(1R,3aS,7aS)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-isopropyl-7a-(5-methyl-5-trimethylsilanyloxy-hexyloxymethyl)-octahydro-indene

Guidance literature:: Multi-step reaction with 9 steps

1: 88 percent / lead tetraacetate, pyridine / benzene / 3.5 h / 15 °C / Irradiation

2: 39 percent / boron trifluoride etherate / -20 deg C, 45 min, room temperature, 1 h

3: 65 percent / potassium hydroxide / methanol / 2.5 h / Heating

4: 94 percent / imidazole / dimethylformamide / 4 h / Ambient temperature

5: 64 percent / potassium hydride, 18-crown-6 / tetrahydrofuran / 0.33 h / Ambient temperature

6: 79 percent / hydrofluoric acid / ethyl acetate; acetonitrile; H₂O / 0.67 h / Ambient temperature

7: 80 percent / pyridinium dichromate / CH₂Cl₂ / 18 h / Ambient temperature

8: 61 percent / N-ethyldiisopropylamine / CH₂Cl₂ / 2.33 h / Ambient temperature

9: 59 percent

With pyridine; 1H-imidazole; lead(IV) acetate; potassium hydroxide; dipyridinium dichromate; 18-crown-6 ether; boron trifluoride diethyl etherate; hydrogen fluoride; potassium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1016/S0968-0896(98)00161-8