2-[4-cyano-2-(2,6-dichlorophenylamino)-7-formyl-3-methyl-3H-benzimidazol-5-yl]-2-methyl-3-oxobutyric acid ethyl ester

Base Information

Chemical Name:2-[4-cyano-2-(2,6-dichlorophenylamino)-7-formyl-3-methyl-3H-benzimidazol-5-yl]-2-methyl-3-oxobutyric acid ethyl ester
CAS No.:333458-64-3
Molecular Formula:C₂₃H₂₀Cl₂N₄O₄
Molecular Weight:487.342
Hs Code.:

Synonyms:2-[4-cyano-2-(2,6-dichlorophenylamino)-7-formyl-3-methyl-3H-benzimidazol-5-yl]-2-methyl-3-oxobutyric acid ethyl ester

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Chemical Property of 2-[4-cyano-2-(2,6-dichlorophenylamino)-7-formyl-3-methyl-3H-benzimidazol-5-yl]-2-methyl-3-oxobutyric acid ethyl ester

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Technology Process of 2-[4-cyano-2-(2,6-dichlorophenylamino)-7-formyl-3-methyl-3H-benzimidazol-5-yl]-2-methyl-3-oxobutyric acid ethyl ester

There total 5 articles about 2-[4-cyano-2-(2,6-dichlorophenylamino)-7-formyl-3-methyl-3H-benzimidazol-5-yl]-2-methyl-3-oxobutyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 333458-62-1
2-[4-cyano-2-(2,6-dichlorophenylamino)-3-methyl-7-vinyl-3H-benzimidazol-5-yl]-2-methyl-3-oxobutyric acid ethyl ester

: 333458-64-3
2-[4-cyano-2-(2,6-dichlorophenylamino)-7-formyl-3-methyl-3H-benzimidazol-5-yl]-2-methyl-3-oxobutyric acid ethyl ester

Guidance literature:: With sodium periodate; osmium(VIII) oxide; In tetrahydrofuran; at 20 ℃; for 0.5h;
DOI:10.1021/jm020446l

Reference yield:

: 333458-41-6
2-(2-cyano-3-methylamino-4-nitrophenyl)-2-methyl-3-oxobutyric acid ethyl ester

: 333458-64-3
2-[4-cyano-2-(2,6-dichlorophenylamino)-7-formyl-3-methyl-3H-benzimidazol-5-yl]-2-methyl-3-oxobutyric acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 81 percent / H₂ / 10 percent Pd/C / ethyl acetate / 24 h / 2585.74 Torr

2: 53 percent / Br₂ / CHCl₃ / 20 °C

3: 71 percent / HgO / dioxane / 95 °C

4: 98 percent / (PPh₃)2PdCl₂; NMP / 72 h / 100 °C

5: 100 percent / OsO₄; aq. NaIO₄ / tetrahydrofuran / 0.5 h / 20 °C

With 1-methyl-pyrrolidin-2-one; bis-triphenylphosphine-palladium(II) chloride; sodium periodate; osmium(VIII) oxide; hydrogen; bromine; mercury(II) oxide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; chloroform; ethyl acetate;
DOI:10.1021/jm020446l

Reference yield:

: 333458-43-8
2-(4-amino-2-cyano-3-methylaminophenyl)-2-methyl-3-oxobutyric acid ethyl ester

: 333458-64-3
2-[4-cyano-2-(2,6-dichlorophenylamino)-7-formyl-3-methyl-3H-benzimidazol-5-yl]-2-methyl-3-oxobutyric acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 53 percent / Br₂ / CHCl₃ / 20 °C

2: 71 percent / HgO / dioxane / 95 °C

3: 98 percent / (PPh₃)2PdCl₂; NMP / 72 h / 100 °C

4: 100 percent / OsO₄; aq. NaIO₄ / tetrahydrofuran / 0.5 h / 20 °C

With 1-methyl-pyrrolidin-2-one; bis-triphenylphosphine-palladium(II) chloride; sodium periodate; osmium(VIII) oxide; bromine; mercury(II) oxide; In tetrahydrofuran; 1,4-dioxane; chloroform;
DOI:10.1021/jm020446l