2-amino-N-(3-(4-(cyclopentylmethoxy)-2-(4-methylpiperazin-1-yl)pyrimidin-5-ylthio)phenyl)acetamide

Base Information

Chemical Name:2-amino-N-(3-(4-(cyclopentylmethoxy)-2-(4-methylpiperazin-1-yl)pyrimidin-5-ylthio)phenyl)acetamide
CAS No.:1268274-01-6
Molecular Formula:C₂₃H₃₂N₆O₂S
Molecular Weight:456.612
Hs Code.:

Synonyms:2-amino-N-(3-(4-(cyclopentylmethoxy)-2-(4-methylpiperazin-1-yl)pyrimidin-5-ylthio)phenyl)acetamide

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Chemical Property of 2-amino-N-(3-(4-(cyclopentylmethoxy)-2-(4-methylpiperazin-1-yl)pyrimidin-5-ylthio)phenyl)acetamide

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Technology Process of 2-amino-N-(3-(4-(cyclopentylmethoxy)-2-(4-methylpiperazin-1-yl)pyrimidin-5-ylthio)phenyl)acetamide

There total 10 articles about 2-amino-N-(3-(4-(cyclopentylmethoxy)-2-(4-methylpiperazin-1-yl)pyrimidin-5-ylthio)phenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₈H₄₀N₆O₄S

: 1268274-01-6
2-amino-N-(3-(4-(cyclopentylmethoxy)-2-(4-methylpiperazin-1-yl)pyrimidin-5-ylthio)phenyl)acetamide

Guidance literature:: C₂₈H₄₀N₆O₄S; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.75h; Inert atmosphere;

With ammonia; In methanol; dichloromethane;

Reference yield:

: 3637-61-4
1-amino-cyclopentanemethanol

: 1268274-01-6
2-amino-N-(3-(4-(cyclopentylmethoxy)-2-(4-methylpiperazin-1-yl)pyrimidin-5-ylthio)phenyl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 20 °C / Inert atmosphere

1.2: 1.5 h / 80 °C

2.1: boron trifluoride - methanol (1/1) / methanol / 5 h / Reflux; Inert atmosphere

3.1: dicyclohexyl-carbodiimide / tetrahydrofuran / 20 °C / Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 0.75 h / 20 °C / Inert atmosphere

With boron trifluoride - methanol (1/1); sodium hydride; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1268273-94-4
5-iodo-4-(4-methoxybenzyloxy)-2-(4-methylpiperazin-1-yl)pyrimidine

: 1268274-01-6
2-amino-N-(3-(4-(cyclopentylmethoxy)-2-(4-methylpiperazin-1-yl)pyrimidin-5-ylthio)phenyl)acetamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium carbonate; copper(I) thiophene-2-carboxylate / N,N-dimethyl-formamide / 25 h / 120 °C / Inert atmosphere

2.1: dichloromethane / 3 h / 20 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 4.08 h / 20 °C / Inert atmosphere

4.1: trichlorophosphate / 2 h / 65 °C / Inert atmosphere

4.2: pH ~ 9

5.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 20 °C / Inert atmosphere

5.2: 1.5 h / 80 °C

6.1: boron trifluoride - methanol (1/1) / methanol / 5 h / Reflux; Inert atmosphere

7.1: dicyclohexyl-carbodiimide / tetrahydrofuran / 20 °C / Inert atmosphere

8.1: trifluoroacetic acid / dichloromethane / 0.75 h / 20 °C / Inert atmosphere

With copper(I) thiophene-2-carboxylate; boron trifluoride - methanol (1/1); sodium hydride; potassium carbonate; dicyclohexyl-carbodiimide; trifluoroacetic acid; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;