N-carbobenzoxy-tyrosyl-glycyl-glycyl-phenylalanyl-(O-methyl)homoserine benzyl ester

Base Information

Chemical Name:N-carbobenzoxy-tyrosyl-glycyl-glycyl-phenylalanyl-(O-methyl)homoserine benzyl ester
CAS No.:85918-28-1
Molecular Formula:C₄₂H₄₇N₅O₁₀
Molecular Weight:781.863
Hs Code.:

Synonyms:N-carbobenzoxy-tyrosyl-glycyl-glycyl-phenylalanyl-(O-methyl)homoserine benzyl ester

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Chemical Property of N-carbobenzoxy-tyrosyl-glycyl-glycyl-phenylalanyl-(O-methyl)homoserine benzyl ester

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Technology Process of N-carbobenzoxy-tyrosyl-glycyl-glycyl-phenylalanyl-(O-methyl)homoserine benzyl ester

There total 5 articles about N-carbobenzoxy-tyrosyl-glycyl-glycyl-phenylalanyl-(O-methyl)homoserine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 3556-56-7
4-nitrophenyl N-[(benzyloxy)carbonyl]-L-tyrosinate

: (S)-2-{(S)-2-[2-(2-Amino-acetylamino)-acetylamino]-3-phenyl-propionylamino}-4-methoxy-butyric acid benzyl ester

: 85918-28-1
N-carbobenzoxy-tyrosyl-glycyl-glycyl-phenylalanyl-(O-methyl)homoserine benzyl ester

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; for 48h; Ambient temperature; pH=7.5;
DOI:10.1016/S0040-4020(01)88549-5

Reference yield:

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 85918-28-1
N-carbobenzoxy-tyrosyl-glycyl-glycyl-phenylalanyl-(O-methyl)homoserine benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 84 percent / N-methyl-morpholine, isobutyl chloroformate / tetrahydrofuran / 3 h

2: 2.) N-methyl-morpholine / 1.) CF₃COOH, CH₂Cl₂, 20 deg C, 45 min; 2.) DMF

3: 1.) DMF, -4 deg C, 15 min, rt, 20 min; 2.) rt, 15 min

4: 1N HCl / acetic acid / 1 h

5: 74 percent / Et₃N / dimethylformamide / 48 h / Ambient temperature; pH=7.5

With 4-methyl-morpholine; hydrogenchloride; triethylamine; isobutyl chloroformate; In tetrahydrofuran; acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)88549-5

Reference yield:

: 85918-19-0
N-t-Butyloxycarbonyl-phenylalanyl-(O-methyl)homoserine benzyl ester

: 85918-28-1
N-carbobenzoxy-tyrosyl-glycyl-glycyl-phenylalanyl-(O-methyl)homoserine benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 2.) N-methyl-morpholine / 1.) CF₃COOH, CH₂Cl₂, 20 deg C, 45 min; 2.) DMF

2: 1.) DMF, -4 deg C, 15 min, rt, 20 min; 2.) rt, 15 min

3: 1N HCl / acetic acid / 1 h

4: 74 percent / Et₃N / dimethylformamide / 48 h / Ambient temperature; pH=7.5

With 4-methyl-morpholine; hydrogenchloride; triethylamine; In acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)88549-5