4-benzyl-1-(3,5-dichlorophenyl)-2-[4-(trifluoromethyl)benzyl]-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine

Base Information

Chemical Name:4-benzyl-1-(3,5-dichlorophenyl)-2-[4-(trifluoromethyl)benzyl]-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine
CAS No.:1284151-71-8
Molecular Formula:C₃₀H₂₅Cl₂F₃N₂
Molecular Weight:541.443
Hs Code.:

Synonyms:4-benzyl-1-(3,5-dichlorophenyl)-2-[4-(trifluoromethyl)benzyl]-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine

Suppliers and Price of 4-benzyl-1-(3,5-dichlorophenyl)-2-[4-(trifluoromethyl)benzyl]-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-benzyl-1-(3,5-dichlorophenyl)-2-[4-(trifluoromethyl)benzyl]-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-benzyl-1-(3,5-dichlorophenyl)-2-[4-(trifluoromethyl)benzyl]-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine

There total 4 articles about 4-benzyl-1-(3,5-dichlorophenyl)-2-[4-(trifluoromethyl)benzyl]-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 402-43-7
p-trifluoromethylphenyl bromide

: 1284151-58-1
N-{2-[(allyl(benzyl)amino)methyl]phenyl}-3,5-dichloroaniline

: 1284151-71-8
4-benzyl-1-(3,5-dichlorophenyl)-2-[4-(trifluoromethyl)benzyl]-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine

Guidance literature:: With dichloro bis(acetonitrile) palladium(II); cyclohexyldiphenylphosphine; sodium t-butanolate; In 5,5-dimethyl-1,3-cyclohexadiene; at 135 ℃; Inert atmosphere;
DOI:10.1021/ol200429a

Reference yield:

: 1284151-63-8
N-allyl-N-benzyl-2-(3,5-dichlorophenylamino)benzamide

: 1284151-71-8
4-benzyl-1-(3,5-dichlorophenyl)-2-[4-(trifluoromethyl)benzyl]-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 0.33 h / 0 - 20 °C / Inert atmosphere

2: dichloro bis(acetonitrile) palladium(II); cyclohexyldiphenylphosphine; sodium t-butanolate / 5,5-dimethyl-1,3-cyclohexadiene / 135 °C / Inert atmosphere

With dichloro bis(acetonitrile) palladium(II); lithium aluminium tetrahydride; cyclohexyldiphenylphosphine; sodium t-butanolate; In tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene; diethyl ether;
DOI:10.1021/ol200429a

Reference yield:

: 18201-65-5
2-(3,5-dichlorophenylamino)benzoic acid

: 1284151-71-8
4-benzyl-1-(3,5-dichlorophenyl)-2-[4-(trifluoromethyl)benzyl]-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine

Guidance literature:: Multi-step reaction with 3 steps

1.1: benzotriazol-1-ol / dichloromethane / 0.03 h / Inert atmosphere

1.2: 15 h / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 0.33 h / 0 - 20 °C / Inert atmosphere

3.1: dichloro bis(acetonitrile) palladium(II); cyclohexyldiphenylphosphine; sodium t-butanolate / 5,5-dimethyl-1,3-cyclohexadiene / 135 °C / Inert atmosphere

With dichloro bis(acetonitrile) palladium(II); lithium aluminium tetrahydride; benzotriazol-1-ol; cyclohexyldiphenylphosphine; sodium t-butanolate; In tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene; diethyl ether; dichloromethane;
DOI:10.1021/ol200429a