4-(4-fluoro-phenyl)-2-methyl-3-oxo-butyric acid ethyl ester

Base Information

• Chemical Name: 4-(4-fluoro-phenyl)-2-methyl-3-oxo-butyric acid ethyl ester
• CAS No.: 221121-43-3
• Molecular Formula: C₁₃H₁₅FO₃
• Molecular Weight: 238.259
• Mol file: 221121-43-3.mol

Synonyms:4-(4-fluoro-phenyl)-2-methyl-3-oxo-butyric acid ethyl ester

Chemical Property of 4-(4-fluoro-phenyl)-2-methyl-3-oxo-butyric acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 4-(4-fluoro-phenyl)-2-methyl-3-oxo-butyric acid ethyl ester

There total 3 articles about 4-(4-fluoro-phenyl)-2-methyl-3-oxo-butyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

potassium ethyl methylmalonate (103362-70-5) + 2-(4-fluorophenyl)-1-(1H-imidazol-1-yl)ethan-1-one (221121-30-8) → 4-(4-fluoro-phenyl)-2-methyl-3-oxo-butyric acid ethyl ester (221121-43-3)

Guidance literature:

With triethylamine; magnesium chloride; Yield given; Multistep reaction; 1.) CH₃CN, RT, 2 h, 2.) CH₃CN, a) RT, overnight, b) reflux, 2 h;

DOI:10.1021/jm980260f

Reference yield:

potassium ethyl methylmalonate (103362-70-5) + p-Fluorophenylacetic acid (405-50-5) → 4-(4-fluoro-phenyl)-2-methyl-3-oxo-butyric acid ethyl ester (221121-43-3)

Guidance literature:

With triethylamine; 1,1'-carbonyldiimidazole; magnesium chloride; In acetonitrile; at 20 ℃;

DOI:10.1016/j.tetlet.2005.10.142

Reference yield:

p-Fluorophenylacetic acid (405-50-5) → 4-(4-fluoro-phenyl)-2-methyl-3-oxo-butyric acid ethyl ester (221121-43-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetonitrile

2.1: MgCl₂; Et₃N / acetonitrile / 2 h / 20 °C

2.2: acetonitrile

With triethylamine; magnesium chloride; In acetonitrile;

DOI:10.1021/jm050744t

upstream raw materials:

potassium ethyl methylmalonate

2-(4-fluorophenyl)-1-(1H-imidazol-1-yl)ethan-1-one

p-Fluorophenylacetic acid

Downstream raw materials:

6-(4-fluoro-benzyl)-5-methyl-2-(4-nitro-benzylsulfanyl)-3H-pyrimidin-4-one

6-(4-fluoro-benzyl)-5-methyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one