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Codeine phosphate hemihydrate

Base Information Edit
  • Chemical Name:Codeine phosphate hemihydrate
  • CAS No.:41444-62-6
  • Deprecated CAS:219853-11-9,277331-89-2
  • Molecular Formula:C36H50N2O15P2
  • Molecular Weight:397.36
  • Hs Code.:2939110000
  • European Community (EC) Number:200-137-8,639-473-9
  • UNII:GSL05Y1MN6
  • DSSTox Substance ID:DTXSID20904612
  • Wikidata:Q27279257
  • NCI Thesaurus Code:C74548
  • RXCUI:2672
  • Mol file:41444-62-6.mol
Codeine phosphate hemihydrate

Synonyms:Ardinex;Codeine;Codeine Phosphate;Isocodeine;Morphinan-6-ol, 7,8-didehydro-4,5-epoxy-3-methoxy-17-methyl-, (5alpha,6alpha)-;N Methylmorphine;N-Methylmorphine

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Codeine phosphate hemihydrate Edit
Chemical Property:
  • Vapor Pressure:2.47E-09mmHg at 25°C 
  • Melting Point:157.5oC 
  • Boiling Point:462 °C at 760 mmHg 
  • Flash Point:233.2 °C 
  • PSA:138.73000 
  • LogP:0.44610 
  • Solubility.:Freely soluble in water, slightly soluble or very slightly soluble in ethanol (96 per cent). 
  • Hydrogen Bond Donor Count:9
  • Hydrogen Bond Acceptor Count:17
  • Rotatable Bond Count:2
  • Exact Mass:812.26864289
  • Heavy Atom Count:55
  • Complexity:558
Purity/Quality:
Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
MSDS Files:

SDS file from LookChem

Useful:
  • Canonical SMILES:CN1CCC23C4C1CC5=C2C(=C(C=C5)OC)OC3C(C=C4)O.CN1CCC23C4C1CC5=C2C(=C(C=C5)OC)OC3C(C=C4)O.O.OP(=O)(O)O.OP(=O)(O)O
  • Isomeric SMILES:CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)OC)O[C@H]3[C@H](C=C4)O.CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)OC)O[C@H]3[C@H](C=C4)O.O.OP(=O)(O)O.OP(=O)(O)O
  • Recent ClinicalTrials:Colonic Motor Patterns in Healthy Volunteers
  • Recent EU Clinical Trials:THE RELATIONSHIP BETWEEN GASTRIC MOTILITY AND EMPTYING AS MEASURED WITH AN INTRAGASTRIC BALLOON AND BREATH TESTING
  • Uses Antitussive; analgesic (narcotic).
  • Clinical Use Codeine is used extensively to treat moderate to mild pain. Codeine is a weak μ agonist, but approximately 10% of an oral dose (30–60 mg) is metabolized to morphine, which contributes significantly to its analgesic effect. The plasma half-life of codeine after oral dose is 3.5 hours. The dose of codeine needed to produce analgesia after parenteral dose causes releases of histamine sufficient to produce hypotension, pruritus, and other allergic responses. Thus, administration of codeine by parenteral route is not recommended.
  • Drug interactions Potentially hazardous interactions with other drugs Antibacterials: metabolism increased by rifampicin. Antidepressants: possible CNS excitation or depression with MAOIs - avoid concomitant use, and for 2 weeks after stopping MAOI; possible CNS excitation or depression with moclobemide; increased sedative effects with tricyclics. Antihistamines: increased sedative effects with sedating antihistamines. Antipsychotics: enhanced hypotensive and sedative effects. Dopaminergics: avoid with selegiline. Nalmefene: avoid concomitant use. Sodium oxybate: enhanced effect of sodium oxybate - avoid.