[((E)-4-(4-methoxyphenyl)but-3-en-2-ylidene)amino]hydroxide

Base Information

• Chemical Name: [((E)-4-(4-methoxyphenyl)but-3-en-2-ylidene)amino]hydroxide
• CAS No.: 1222558-29-3
• Molecular Formula: C₁₁H₁₃NO₂
• Molecular Weight: 191.23
• Mol file: 1222558-29-3.mol

Synonyms:[((E)-4-(4-methoxyphenyl)but-3-en-2-ylidene)amino]hydroxide

Chemical Property of [((E)-4-(4-methoxyphenyl)but-3-en-2-ylidene)amino]hydroxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of [((E)-4-(4-methoxyphenyl)but-3-en-2-ylidene)amino]hydroxide

There total 2 articles about [((E)-4-(4-methoxyphenyl)but-3-en-2-ylidene)amino]hydroxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(4-methoxyphenyl)-3-buten-2-one (3815-30-3) → [((E)-4-(4-methoxyphenyl)but-3-en-2-ylidene)amino]hydroxide (1222558-29-3)

Guidance literature:

With TEA; hydroxylamine hydrochloride;

DOI:10.1080/00397910601055107

Reference yield:

(E)-1-(4-methoxyphenyl)pent-1-en-3-ol (32271-54-8,134747-45-8,77254-94-5) → [((E)-4-(4-methoxyphenyl)but-3-en-2-ylidene)amino]hydroxide (1222558-29-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; oxygen / tert-butyl methyl ether / 16 h / 30 °C / pH 5 / Enzymatic reaction

2: sodium hydroxide; hydroxylamine hydrochloride / water; ethanol / Reflux

With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; hydroxylamine hydrochloride; oxygen; sodium hydroxide; In ethanol; tert-butyl methyl ether; water;

DOI:10.1002/cbic.201900473

Reference yield: 75.0%

[((E)-4-(4-methoxyphenyl)but-3-en-2-ylidene)amino]hydroxide (1222558-29-3) + ethyl acetoacetate (141-97-9) → 4-(4-methoxy-phenyl)-2,6-dimethyl-nicotinic acid ethyl ester (629628-27-9)

Guidance literature:

With indium(III) chloride; for 7h; Heating;

DOI:10.1016/j.tetlet.2003.09.144

upstream raw materials:

4-(4-methoxyphenyl)-3-buten-2-one

(E)-1-(4-methoxyphenyl)pent-1-en-3-ol

Downstream raw materials:

(+)-(R)-1-Methyl-3-(4-methoxyphenyl)-1-propylamine

5-(4-methoxy-phenyl)-3-methyl-4,5-dihydro-isoxazol-4-ol

4-(4-methoxy-phenyl)-2,6-dimethyl-nicotinic acid ethyl ester

5-(4-methoxyphenyl)-3-methylisoxazole