C₂₄H₁₉F₃N₄O₃

Base Information

• Chemical Name: C₂₄H₁₉F₃N₄O₃
• CAS No.: 1609271-52-4
• Molecular Formula: C₂₄H₁₉F₃N₄O₃
• Molecular Weight: 468.435
• Mol file: 1609271-52-4.mol

Synonyms:C₂₄H₁₉F₃N₄O₃

Chemical Property of C₂₄H₁₉F₃N₄O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₄H₁₉F₃N₄O₃

There total 3 articles about C₂₄H₁₉F₃N₄O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-amino-2-hydroxypyridine (38767-72-5,59315-45-6) + C19H14F3IN2O2 (1609271-51-3) → C24H19F3N4O3 (1609271-52-4)

Guidance literature:

With copper(l) iodide; dimethylaminoacetic acid; potassium carbonate; In dimethyl sulfoxide; at 130 ℃; for 10h; Sonication; Inert atmosphere;

Reference yield:

4-iodo-1-(4-methoxybenzyl)-1H-imidazole (1214247-82-1) → C24H19F3N4O3 (1609271-52-4)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / acetonitrile / Reflux

2: potassium carbonate; dimethylaminoacetic acid; copper(l) iodide / dimethyl sulfoxide / 10 h / 130 °C / Sonication; Inert atmosphere

With copper(l) iodide; dimethylaminoacetic acid; potassium carbonate; triethylamine; In dimethyl sulfoxide; acetonitrile;

Reference yield:

p-methoxybenzyl chloride (824-94-2) → C24H19F3N4O3 (1609271-52-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 0 °C

1.2: 20 °C

2.1: triethylamine / acetonitrile / Reflux

3.1: potassium carbonate; dimethylaminoacetic acid; copper(l) iodide / dimethyl sulfoxide / 10 h / 130 °C / Sonication; Inert atmosphere

With copper(l) iodide; dimethylaminoacetic acid; sodium hydride; potassium carbonate; triethylamine; In tetrahydrofuran; dimethyl sulfoxide; acetonitrile; mineral oil;

upstream raw materials:

4-iodo-1-(4-methoxybenzyl)-1H-imidazole

4-amino-2-hydroxypyridine

C₁₉H₁₄F₃IN₂O₂

p-methoxybenzyl chloride

Downstream raw materials:

C₂₁H₁₆F₃N₅O₃S

C₂₁H₁₆F₃N₅O₂S