N-Benzyloxycarbonyl-(RS)-(5-benzyloxy-2-pyridyl)glycyl-glycylglycinbenzylester

Base Information

• Chemical Name: N-Benzyloxycarbonyl-(RS)-(5-benzyloxy-2-pyridyl)glycyl-glycylglycinbenzylester
• CAS No.: 112613-27-1
• Molecular Formula: C₃₃H₃₂N₄O₇
• Molecular Weight: 596.64
• Mol file: 112613-27-1.mol

Synonyms:N-Benzyloxycarbonyl-(RS)-(5-benzyloxy-2-pyridyl)glycyl-glycylglycinbenzylester

Chemical Property of N-Benzyloxycarbonyl-(RS)-(5-benzyloxy-2-pyridyl)glycyl-glycylglycinbenzylester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-Benzyloxycarbonyl-(RS)-(5-benzyloxy-2-pyridyl)glycyl-glycylglycinbenzylester

There total 3 articles about N-Benzyloxycarbonyl-(RS)-(5-benzyloxy-2-pyridyl)glycyl-glycylglycinbenzylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

glycylglycine benzyl ester p-toluene sulfonate salt (1738-82-5) + N-Benzyloxycarbonyl-(RS)-(5-benzyloxy-2-pyridyl)glycin (112613-15-7) → N-Benzyloxycarbonyl-(RS)-(5-benzyloxy-2-pyridyl)glycyl-glycylglycinbenzylester (112613-27-1)

Guidance literature:

With 1-hydroxy-pyrrolidine-2,5-dione; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; for 15h;

DOI:10.1002/ardp.19873200612

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → N-Benzyloxycarbonyl-(RS)-(5-benzyloxy-2-pyridyl)glycyl-glycylglycinbenzylester (112613-27-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 61 percent / aq. NaOH / 3 h

2: 65 percent / N-hydroxysuccinimide, DCC, Et₃N / CH₂Cl₂ / 15 h

With sodium hydroxide; 1-hydroxy-pyrrolidine-2,5-dione; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1002/ardp.19873200612

Reference yield:

(5-benzyloxy-2-pyridyl)glycine (108158-23-2) → N-Benzyloxycarbonyl-(RS)-(5-benzyloxy-2-pyridyl)glycyl-glycylglycinbenzylester (112613-27-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 61 percent / aq. NaOH / 3 h

2: 65 percent / N-hydroxysuccinimide, DCC, Et₃N / CH₂Cl₂ / 15 h

With sodium hydroxide; 1-hydroxy-pyrrolidine-2,5-dione; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1002/ardp.19873200612

upstream raw materials:

glycylglycine benzyl ester p-toluene sulfonate salt

N-Benzyloxycarbonyl-(RS)-(5-benzyloxy-2-pyridyl)glycin

benzyl chloroformate

(5-benzyloxy-2-pyridyl)glycine