Technology Process of 2,3,5,6-tetrafluorobenzyl (1R)-cis-3-cyano-2,2-dimethylcyclopropane carboxylate
There total 3 articles about 2,3,5,6-tetrafluorobenzyl (1R)-cis-3-cyano-2,2-dimethylcyclopropane carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
dmap;
In
chloroform;
at 20 ℃;
for 18h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: acetic anhydride / 4 h / 20 - 120 °C
2: potassium permanganate; sodium periodate / water; tert-butyl alcohol / 120 h / 20 °C
3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dmap / chloroform / 18 h / 20 °C
With
potassium permanganate; sodium periodate; acetic anhydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
dmap;
In
chloroform; water; tert-butyl alcohol;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: oxalyl dichloride; triethylamine / tetrahydrofuran / 12 h / 0 - 20 °C
1.2: 2 h / 20 °C
2.1: acetic anhydride / 4 h / 20 - 120 °C
3.1: potassium permanganate; sodium periodate / water; tert-butyl alcohol / 120 h / 20 °C
4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dmap / chloroform / 18 h / 20 °C
With
potassium permanganate; sodium periodate; oxalyl dichloride; acetic anhydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
dmap;
In
tetrahydrofuran; chloroform; water; tert-butyl alcohol;
