(S)-1-[(R)-4-((S)-2-Benzyloxycarbonylamino-6-tert-butoxycarbonylamino-hexanoylamino)-4-carboxy-butyryl]-2,3-dihydro-1H-indole-2-carboxylic acid

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Chemical Name:(S)-1-[(R)-4-((S)-2-Benzyloxycarbonylamino-6-tert-butoxycarbonylamino-hexanoylamino)-4-carboxy-butyryl]-2,3-dihydro-1H-indole-2-carboxylic acid
CAS No.:116586-14-2
Molecular Formula:C₃₃H₄₂N₄O₁₀
Molecular Weight:654.717
Hs Code.:

Synonyms:(S)-1-[(R)-4-((S)-2-Benzyloxycarbonylamino-6-tert-butoxycarbonylamino-hexanoylamino)-4-carboxy-butyryl]-2,3-dihydro-1H-indole-2-carboxylic acid

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Chemical Property of (S)-1-[(R)-4-((S)-2-Benzyloxycarbonylamino-6-tert-butoxycarbonylamino-hexanoylamino)-4-carboxy-butyryl]-2,3-dihydro-1H-indole-2-carboxylic acid

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Technology Process of (S)-1-[(R)-4-((S)-2-Benzyloxycarbonylamino-6-tert-butoxycarbonylamino-hexanoylamino)-4-carboxy-butyryl]-2,3-dihydro-1H-indole-2-carboxylic acid

There total 6 articles about (S)-1-[(R)-4-((S)-2-Benzyloxycarbonylamino-6-tert-butoxycarbonylamino-hexanoylamino)-4-carboxy-butyryl]-2,3-dihydro-1H-indole-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 116586-13-1
(S)-1-[(R)-4-((S)-2-Benzyloxycarbonylamino-6-tert-butoxycarbonylamino-hexanoylamino)-4-ethoxycarbonyl-butyryl]-2,3-dihydro-1H-indole-2-carboxylic acid ethyl ester

: 116586-14-2
(S)-1-[(R)-4-((S)-2-Benzyloxycarbonylamino-6-tert-butoxycarbonylamino-hexanoylamino)-4-carboxy-butyryl]-2,3-dihydro-1H-indole-2-carboxylic acid

Guidance literature:: With sodium hydroxide; In ethanol; for 1.5h;
DOI:10.1248/cpb.37.2417

Reference yield:

: 79854-42-5
Ethyl (S)-indoline-2-carboxylate hydrochloride

: 116586-14-2
(S)-1-[(R)-4-((S)-2-Benzyloxycarbonylamino-6-tert-butoxycarbonylamino-hexanoylamino)-4-carboxy-butyryl]-2,3-dihydro-1H-indole-2-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 70 percent / EDC*HCl, triethylamine / CH₂Cl₂ / 5 h

2: 81 percent / H₂ / 5percent Pd/C / methanol; acetic acid / 2 h

3: 90 percent / EDC*HCl / CH₂Cl₂

4: 90 percent / 1N NaOH / ethanol / 1.5 h

With sodium hydroxide; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In methanol; ethanol; dichloromethane; acetic acid;
DOI:10.1248/cpb.37.2417

Reference yield:

: 97975-53-6
ethyl 1-<4-(N-carbobenzoxyamino)-4-carboethoxy-4(R)-butyryl>indoline-2(S)-carboxylic acid

: 116586-14-2
(S)-1-[(R)-4-((S)-2-Benzyloxycarbonylamino-6-tert-butoxycarbonylamino-hexanoylamino)-4-carboxy-butyryl]-2,3-dihydro-1H-indole-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / H₂ / 5percent Pd/C / methanol; acetic acid / 2 h

2: 90 percent / EDC*HCl / CH₂Cl₂

3: 90 percent / 1N NaOH / ethanol / 1.5 h

With sodium hydroxide; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In methanol; ethanol; dichloromethane; acetic acid;
DOI:10.1248/cpb.37.2417