(R)-((1-(2-allylamino)-2-oxoethyl)-5-(4-bromophenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)methyl 4-chloro-2-(trifluoromethyl)phenylcarbamate

Base Information

Chemical Name:(R)-((1-(2-allylamino)-2-oxoethyl)-5-(4-bromophenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)methyl 4-chloro-2-(trifluoromethyl)phenylcarbamate
CAS No.:1242185-38-1
Molecular Formula:C₂₉H₂₃BrClF₃N₄O₄
Molecular Weight:663.878
Hs Code.:

(R)-((1-(2-allylamino)-2-oxoethyl)-5-(4-bromophenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)methyl 4-chloro-2-(trifluoromethyl)phenylcarbamate

Synonyms:(R)-((1-(2-allylamino)-2-oxoethyl)-5-(4-bromophenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)methyl 4-chloro-2-(trifluoromethyl)phenylcarbamate

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Chemical Property of (R)-((1-(2-allylamino)-2-oxoethyl)-5-(4-bromophenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)methyl 4-chloro-2-(trifluoromethyl)phenylcarbamate

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Technology Process of (R)-((1-(2-allylamino)-2-oxoethyl)-5-(4-bromophenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)methyl 4-chloro-2-(trifluoromethyl)phenylcarbamate

There total 1 articles about (R)-((1-(2-allylamino)-2-oxoethyl)-5-(4-bromophenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)methyl 4-chloro-2-(trifluoromethyl)phenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.5%

: 1242185-34-7
N-allyl-2-(5-(4-bromo-phenyl)-3-hydroxymethyl-2-oxo-2,3-dihydro-benzo[e][1,4]diazepin-1-yl)acetamide

: 16588-69-5
4-chloro-2-trifluoromethylphenylisocyanate

: 1242185-38-1
(R)-((1-(2-allylamino)-2-oxoethyl)-5-(4-bromophenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)methyl 4-chloro-2-(trifluoromethyl)phenylcarbamate

Guidance literature:: In dichloromethane; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1016/j.bmc.2010.06.010

Reference yield: 98.2%

: 1242185-38-1
(R)-((1-(2-allylamino)-2-oxoethyl)-5-(4-bromophenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)methyl 4-chloro-2-(trifluoromethyl)phenylcarbamate

: 292638-85-8,9003-21-8,96-33-3
acrylic acid methyl ester

: (R)-methyl 4-(2-(5-(4-bromophenyl)-3-((4-chloro-2-(trifluoromethyl)phenylcarbamoyloxy)methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)acetamido))but-2-enoate

Guidance literature:: With Hoveyda-Grubbs catalyst second generation; In dichloromethane; at 100 ℃; for 2h; Microwave irradiation;
DOI:10.1016/j.bmc.2010.06.010