(S)-3-Benzyloxy-2-{(2S,3R)-2-[(S)-2-(tert-butoxycarbonyl-ethyl-amino)-4-methyl-pentanoylamino]-3-methyl-pentanoylamino}-propionic acid allyl ester

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Chemical Name:(S)-3-Benzyloxy-2-{(2S,3R)-2-[(S)-2-(tert-butoxycarbonyl-ethyl-amino)-4-methyl-pentanoylamino]-3-methyl-pentanoylamino}-propionic acid allyl ester
CAS No.:694527-73-6
Molecular Formula:C₃₂H₅₁N₃O₇
Molecular Weight:589.773
Hs Code.:

Synonyms:(S)-3-Benzyloxy-2-{(2S,3R)-2-[(S)-2-(tert-butoxycarbonyl-ethyl-amino)-4-methyl-pentanoylamino]-3-methyl-pentanoylamino}-propionic acid allyl ester

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Chemical Property of (S)-3-Benzyloxy-2-{(2S,3R)-2-[(S)-2-(tert-butoxycarbonyl-ethyl-amino)-4-methyl-pentanoylamino]-3-methyl-pentanoylamino}-propionic acid allyl ester

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Technology Process of (S)-3-Benzyloxy-2-{(2S,3R)-2-[(S)-2-(tert-butoxycarbonyl-ethyl-amino)-4-methyl-pentanoylamino]-3-methyl-pentanoylamino}-propionic acid allyl ester

There total 4 articles about (S)-3-Benzyloxy-2-{(2S,3R)-2-[(S)-2-(tert-butoxycarbonyl-ethyl-amino)-4-methyl-pentanoylamino]-3-methyl-pentanoylamino}-propionic acid allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 2-(tert-butoxycarbonyl-ethyl-amino)-4-methyl-pentanoic acid

: L-allo-isoleucine-O-benzyl-L-serine allyl ester hydrochloride

: 694527-73-6
(S)-3-Benzyloxy-2-{(2S,3R)-2-[(S)-2-(tert-butoxycarbonyl-ethyl-amino)-4-methyl-pentanoylamino]-3-methyl-pentanoylamino}-propionic acid allyl ester

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1016/j.bmc.2003.10.055

Reference yield:

: 13139-16-7,35264-07-4,55721-65-8,55780-90-0,116194-21-9
Boc-L-aIle-OH

: 694527-73-6
(S)-3-Benzyloxy-2-{(2S,3R)-2-[(S)-2-(tert-butoxycarbonyl-ethyl-amino)-4-methyl-pentanoylamino]-3-methyl-pentanoylamino}-propionic acid allyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: PyBOP; Et₃N / CH₂Cl₂ / 0 - 20 °C

2: HCl / ethyl acetate / 20 °C

3: 94 percent / PyBOP; Et₃N / CH₂Cl₂ / 0 - 20 °C

With hydrogenchloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; In dichloromethane; ethyl acetate;
DOI:10.1016/j.bmc.2003.10.055

Reference yield:

: O-benzyl-L-serine allyl ester hydrochloride

: 694527-73-6
(S)-3-Benzyloxy-2-{(2S,3R)-2-[(S)-2-(tert-butoxycarbonyl-ethyl-amino)-4-methyl-pentanoylamino]-3-methyl-pentanoylamino}-propionic acid allyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: PyBOP; Et₃N / CH₂Cl₂ / 0 - 20 °C

2: HCl / ethyl acetate / 20 °C

3: 94 percent / PyBOP; Et₃N / CH₂Cl₂ / 0 - 20 °C

With hydrogenchloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; In dichloromethane; ethyl acetate;
DOI:10.1016/j.bmc.2003.10.055