(3R,5S)-3-{(R)-15-Hydroxy-15-[(2R,5R)-5-((R)-1-hydroxy-tridecyl)-tetrahydro-furan-2-yl]-pentadecyl}-5-methyl-3-phenylsulfanyl-dihydro-furan-2-one

Base Information

Chemical Name:(3R,5S)-3-{(R)-15-Hydroxy-15-[(2R,5R)-5-((R)-1-hydroxy-tridecyl)-tetrahydro-furan-2-yl]-pentadecyl}-5-methyl-3-phenylsulfanyl-dihydro-furan-2-one
CAS No.:148123-48-2
Molecular Formula:C₄₃H₇₄O₅S
Molecular Weight:703.124
Hs Code.:

Synonyms:(3R,5S)-3-{(R)-15-Hydroxy-15-[(2R,5R)-5-((R)-1-hydroxy-tridecyl)-tetrahydro-furan-2-yl]-pentadecyl}-5-methyl-3-phenylsulfanyl-dihydro-furan-2-one

Suppliers and Price of (3R,5S)-3-{(R)-15-Hydroxy-15-[(2R,5R)-5-((R)-1-hydroxy-tridecyl)-tetrahydro-furan-2-yl]-pentadecyl}-5-methyl-3-phenylsulfanyl-dihydro-furan-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3R,5S)-3-{(R)-15-Hydroxy-15-[(2R,5R)-5-((R)-1-hydroxy-tridecyl)-tetrahydro-furan-2-yl]-pentadecyl}-5-methyl-3-phenylsulfanyl-dihydro-furan-2-one

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3R,5S)-3-{(R)-15-Hydroxy-15-[(2R,5R)-5-((R)-1-hydroxy-tridecyl)-tetrahydro-furan-2-yl]-pentadecyl}-5-methyl-3-phenylsulfanyl-dihydro-furan-2-one

There total 16 articles about (3R,5S)-3-{(R)-15-Hydroxy-15-[(2R,5R)-5-((R)-1-hydroxy-tridecyl)-tetrahydro-furan-2-yl]-pentadecyl}-5-methyl-3-phenylsulfanyl-dihydro-furan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: (3R,5S)-3-{(E)-(R)-15-Hydroxy-15-[(2R,5R)-5-((R)-1-hydroxy-tridecyl)-tetrahydro-furan-2-yl]-pentadec-11-en-9-ynyl}-5-methyl-3-phenylsulfanyl-dihydro-furan-2-one

: 148123-48-2
(3R,5S)-3-{(R)-15-Hydroxy-15-[(2R,5R)-5-((R)-1-hydroxy-tridecyl)-tetrahydro-furan-2-yl]-pentadecyl}-5-methyl-3-phenylsulfanyl-dihydro-furan-2-one

Guidance literature:: With RhCl(PPh₃)3; hydrogen; In acetone; benzene; for 16h; under 760 Torr;
DOI:10.1021/ja00064a060

Reference yield:

: 184435-75-4
(5S)-5-methyl-3-phenylsulfanyl-4,5-dihydrofuran-2(3H)-one

: 148123-48-2
(3R,5S)-3-{(R)-15-Hydroxy-15-[(2R,5R)-5-((R)-1-hydroxy-tridecyl)-tetrahydro-furan-2-yl]-pentadecyl}-5-methyl-3-phenylsulfanyl-dihydro-furan-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hexamethyldisilazide / 1.) THF, 0 deg C, 2.) THF, reflux, 2 h

2: 70 percent / Pd(PPh₃)4, Et₃N, CuI / tetrahydrofuran / 2 h / 50 °C

3: 95 percent / RhCl(PPh₃)3, H₂ / benzene; acetone / 16 h / 760 Torr

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; RhCl(PPh₃)3; hydrogen; potassium hexamethylsilazane; triethylamine; In tetrahydrofuran; acetone; benzene;
DOI:10.1021/ja00064a060

Reference yield:

: 145285-55-8
trans ethyl heptadec-4-enoate

: 148123-48-2
(3R,5S)-3-{(R)-15-Hydroxy-15-[(2R,5R)-5-((R)-1-hydroxy-tridecyl)-tetrahydro-furan-2-yl]-pentadecyl}-5-methyl-3-phenylsulfanyl-dihydro-furan-2-one

Guidance literature:: Multi-step reaction with 13 steps

1: LiAlH₄

2: pyridinium chlorochromate / CH₂Cl₂

4: propionic acid

5: 66 percent / AD-mix-β, methanesulfonamide / 2-methyl-propan-2-ol; H2O / 16 h / 0 °C

6: 98 percent / TsOH / acetone / 1 h / 0 - 25 °C

7: 97 percent / triethylamine, 4-(dimethylamino)pyridine / CH₂Cl₂ / 48 h / Ambient temperature

8: 88 percent / K₂CO₃ / 1 h / Ambient temperature

9: 75 percent / BF₃*Et₂O / CH₂Cl₂

10: diisobutylaluminum hydride / tetrahydrofuran / 1 h / -50 °C

11: 1.) potassium tert-butoxide / 1.) THF, -78 deg C, 1 h, 2.) THF, -78 deg C, 1 h

12: 70 percent / Pd(PPh₃)4, Et₃N, CuI / tetrahydrofuran / 2 h / 50 °C

13: 95 percent / RhCl(PPh₃)3, H₂ / benzene; acetone / 16 h / 760 Torr

With dmap; copper(l) iodide; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; methanesulfonamide; RhCl(PPh₃)3; AD-mix-β; boron trifluoride diethyl etherate; potassium tert-butylate; hydrogen; diisobutylaluminium hydride; potassium carbonate; toluene-4-sulfonic acid; propionic acid; triethylamine; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; water; acetone; tert-butyl alcohol; benzene;
DOI:10.1021/ja00064a060