(S)-2-{(S)-2-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenylselanyl-propionylamino)-propionyloxy]-3-methyl-butyrylamino}-5-(4-methoxy-phenyl)-pentanoic acid tert-butyl ester

Base Information

Chemical Name:(S)-2-{(S)-2-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenylselanyl-propionylamino)-propionyloxy]-3-methyl-butyrylamino}-5-(4-methoxy-phenyl)-pentanoic acid tert-butyl ester
CAS No.:178861-41-1
Molecular Formula:C₃₈H₅₅N₃O₉Se
Molecular Weight:776.829
Hs Code.:

(S)-2-{(S)-2-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenylselanyl-propionylamino)-propionyloxy]-3-methyl-butyrylamino}-5-(4-methoxy-phenyl)-pentanoic acid tert-butyl ester

Synonyms:(S)-2-{(S)-2-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenylselanyl-propionylamino)-propionyloxy]-3-methyl-butyrylamino}-5-(4-methoxy-phenyl)-pentanoic acid tert-butyl ester

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Chemical Property of (S)-2-{(S)-2-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenylselanyl-propionylamino)-propionyloxy]-3-methyl-butyrylamino}-5-(4-methoxy-phenyl)-pentanoic acid tert-butyl ester

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Technology Process of (S)-2-{(S)-2-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenylselanyl-propionylamino)-propionyloxy]-3-methyl-butyrylamino}-5-(4-methoxy-phenyl)-pentanoic acid tert-butyl ester

There total 18 articles about (S)-2-{(S)-2-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenylselanyl-propionylamino)-propionyloxy]-3-methyl-butyrylamino}-5-(4-methoxy-phenyl)-pentanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 178861-37-5
N-(tert-butoxycarbonyl)-L-(Se)-phenylselenocysteine

: (S)-2-[(S)-2-((S)-2-Amino-propionyloxy)-3-methyl-butyrylamino]-5-(4-methoxy-phenyl)-pentanoic acid tert-butyl ester; hydrochloride

: 178861-41-1
(S)-2-{(S)-2-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenylselanyl-propionylamino)-propionyloxy]-3-methyl-butyrylamino}-5-(4-methoxy-phenyl)-pentanoic acid tert-butyl ester

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide;
DOI:10.1039/CC9960001139

Reference yield:

: 17407-55-5
(S)-2-Hydroxy-3-methylbutanoic acid

: 178861-41-1
(S)-2-{(S)-2-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenylselanyl-propionylamino)-propionyloxy]-3-methyl-butyrylamino}-5-(4-methoxy-phenyl)-pentanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 88 percent / Et₃N

2: 93 percent / DCC, DMAP

3: 99 percent / H₂ / 10percent Pd/C

4: 99 percent / DCC, HOBT, NMM

5: 85 percent / HCl / ethyl acetate

6: 94 percent / EDC, HOBT

With 4-methyl-morpholine; hydrogenchloride; dmap; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In ethyl acetate;
DOI:10.1039/CC9960001139

Reference yield:

: 65138-05-8
(S)-2-hydroxy-3-methylbutyric acid benzyl ester

: 178861-41-1
(S)-2-{(S)-2-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenylselanyl-propionylamino)-propionyloxy]-3-methyl-butyrylamino}-5-(4-methoxy-phenyl)-pentanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 93 percent / DCC, DMAP

2: 99 percent / H₂ / 10percent Pd/C

3: 99 percent / DCC, HOBT, NMM

4: 85 percent / HCl / ethyl acetate

5: 94 percent / EDC, HOBT

With 4-methyl-morpholine; hydrogenchloride; dmap; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; dicyclohexyl-carbodiimide; palladium on activated charcoal; In ethyl acetate;
DOI:10.1039/CC9960001139