(6R-cis)-7-amino-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-7-(methylthio)-8-oxo-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylic acid diphenylmethyl ester

Base Information

Chemical Name:(6R-cis)-7-amino-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-7-(methylthio)-8-oxo-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylic acid diphenylmethyl ester
CAS No.:67366-04-5
Molecular Formula:C₂₄H₂₄N₆O₃S₃
Molecular Weight:540.691
Hs Code.:

(6R-cis)-7-amino-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-7-(methylthio)-8-oxo-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylic acid diphenylmethyl ester

Synonyms:(6R-cis)-7-amino-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-7-(methylthio)-8-oxo-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylic acid diphenylmethyl ester

Suppliers and Price of (6R-cis)-7-amino-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-7-(methylthio)-8-oxo-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylic acid diphenylmethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of (6R-cis)-7-amino-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-7-(methylthio)-8-oxo-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylic acid diphenylmethyl ester

Chemical Property:

Purity/Quality:: 95%+ or 98%+ ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (6R-cis)-7-amino-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-7-(methylthio)-8-oxo-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylic acid diphenylmethyl ester

There total 5 articles about (6R-cis)-7-amino-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-7-(methylthio)-8-oxo-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylic acid diphenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 64278-70-2
(6R)-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-7-(methylthioimino)-8-oxo-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylic acid diphenylmethyl ester

: 67366-04-5
(6R-cis)-7-amino-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-7-(methylthio)-8-oxo-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylic acid diphenylmethyl ester

Guidance literature:: With triphenylphosphine; In dichloromethane; at 26 ℃; for 12h; Mallinckrodt SilicAR CC-4;
DOI:10.1021/ja00525a038

Reference yield:

: 7α-methylthio-7-(4-nitrobenzalimino)-3-(1-methyl-1H-tetrazol-5-yl)thiomethyl-Δ³-cephem-4-carboxylic acid diphenylmethyl ester

: 67366-04-5
(6R-cis)-7-amino-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-7-(methylthio)-8-oxo-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylic acid diphenylmethyl ester

Guidance literature:: With toluene-4-sulfonic acid; In 1,2-dimethoxyethane; at 25 ℃; for 2h; Yield given;
DOI:10.1021/ja00525a038

Reference yield:

: 73711-24-7
7-(4-nitrobenzalimino)-3-(1-methyl-1H-tetrazol-5-yl)thiomethyl-Δ³-cephem-4-carboxylic acid diphenylmethyl ester

: 67366-04-5
(6R-cis)-7-amino-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-7-(methylthio)-8-oxo-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylic acid diphenylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 28 percent / KO-t-Bu / 1,2-dimethoxy-ethane / 0.5 h / -60 °C

2: p-toluenesulfonic acid / 1,2-dimethoxy-ethane / 2 h / 25 °C

With potassium tert-butylate; toluene-4-sulfonic acid; In 1,2-dimethoxyethane;
DOI:10.1021/ja00525a038