1,1-Dicyclohexyl-prop-2-yn-1-ol

Base Information

• Chemical Name: 1,1-Dicyclohexyl-prop-2-yn-1-ol
• CAS No.: 10562-70-6
• Molecular Formula: C₁₅H₂₄O
• Molecular Weight: 220.355
• European Community (EC) Number: 653-747-5
• Mol file: 10562-70-6.mol

Synonyms:1,1-dicyclohexyl-prop-2-yn-1-ol;SCHEMBL928079;AKOS024323764

Chemical Property of 1,1-Dicyclohexyl-prop-2-yn-1-ol

Chemical Property:

• XLogP3: 4.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 220.182715385
• Heavy Atom Count: 16
• Complexity: 242

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C#CC(C1CCCCC1)(C2CCCCC2)O

Technology Process of 1,1-Dicyclohexyl-prop-2-yn-1-ol

There total 5 articles about 1,1-Dicyclohexyl-prop-2-yn-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

dicyclohexyl ketone (119-60-8) + trimethylsilylacetylene (1066-54-2) → 1,1-dicyclohexylprop-2-yn-1-ol (10562-70-6)

Guidance literature:

trimethylsilylacetylene; With n-butyllithium; In tetrahydrofuran; hexane; at -10 ℃; for 1h; Inert atmosphere;

dicyclohexyl ketone; In tetrahydrofuran; hexane; at -10 - 0 ℃; for 3h; Inert atmosphere;

With sodium hydroxide; In tetrahydrofuran; methanol; hexane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/acs.jmedchem.6b01482

Reference yield:

dicyclohexyl ketone (119-60-8) + acetylenemagnesium bromide (4301-14-8) → 1,1-dicyclohexylprop-2-yn-1-ol (10562-70-6)

Guidance literature:

In tetrahydrofuran; at -10 - 20 ℃;

DOI:10.1021/ol302730x

Reference yield:

dicyclohexyl ketone (119-60-8) + lithium acetylide (70277-75-7) → 1,1-dicyclohexylprop-2-yn-1-ol (10562-70-6)

Guidance literature:

In tetrahydrofuran; for 16h; Ambient temperature;

DOI:10.1021/jm00114a016

upstream raw materials:

dicyclohexyl ketone

lithium acetylide

acetylenemagnesium bromide

trimethylsilylacetylene

Downstream raw materials:

(E)-1,4-dibromo-1,4-dicyclohexylidenebut-2-ene

1,1-Dicyclohexyl-7-dimethylamino-1-hydroxy-hept-5-yn-2-one