5-chloro-2-fluoro-4-[(3-isopropylimidazo[1,5-a]pyridin-6-yl)methoxy]-N-(methylsulfonyl)benzamide

Base Information

Chemical Name:5-chloro-2-fluoro-4-[(3-isopropylimidazo[1,5-a]pyridin-6-yl)methoxy]-N-(methylsulfonyl)benzamide
CAS No.:1355488-35-5
Molecular Formula:C₁₉H₁₉ClFN₃O₄S
Molecular Weight:439.895
Hs Code.:

Synonyms:5-chloro-2-fluoro-4-[(3-isopropylimidazo[1,5-a]pyridin-6-yl)methoxy]-N-(methylsulfonyl)benzamide

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Chemical Property of 5-chloro-2-fluoro-4-[(3-isopropylimidazo[1,5-a]pyridin-6-yl)methoxy]-N-(methylsulfonyl)benzamide

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Technology Process of 5-chloro-2-fluoro-4-[(3-isopropylimidazo[1,5-a]pyridin-6-yl)methoxy]-N-(methylsulfonyl)benzamide

There total 5 articles about 5-chloro-2-fluoro-4-[(3-isopropylimidazo[1,5-a]pyridin-6-yl)methoxy]-N-(methylsulfonyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 1354960-67-0
5-chloro-2,4-difluoro-N-(methylsulfonyl)benzamide

: 1355489-10-9
(3-isopropylimidazo[1,5-a]pyridin-6-yl)methanol

: 1355488-35-5
5-chloro-2-fluoro-4-[(3-isopropylimidazo[1,5-a]pyridin-6-yl)methoxy]-N-(methylsulfonyl)benzamide

Guidance literature:: (3-isopropylimidazo[1,5-a]pyridin-6-yl)methanol; With sodium hydride; In tetrahydrofuran; mineral oil; at 55 ℃; for 0.5h;

5-chloro-2,4-difluoro-N-(methylsulfonyl)benzamide; In dimethyl sulfoxide; mineral oil; at 20 ℃; for 18h;

With hydrogenchloride; In water; pH=6;

Reference yield:

: 1072438-56-2
methyl 6-(aminomethyl)nicotinate hydrochloride

: 1355488-35-5
5-chloro-2-fluoro-4-[(3-isopropylimidazo[1,5-a]pyridin-6-yl)methoxy]-N-(methylsulfonyl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / cooling with ice

2.1: trichlorophosphate / toluene / 3 h / Inert atmosphere; Reflux

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 20 °C / cooling with ice

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 55 °C

4.2: 18 h / 20 °C

4.3: pH 6

With lithium aluminium tetrahydride; sodium hydride; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; dichloromethane; toluene; mineral oil;

Reference yield:

: 1355489-07-4
methyl 6-[(isobutyrylamino)methyl]nicotinate

: 1355488-35-5
5-chloro-2-fluoro-4-[(3-isopropylimidazo[1,5-a]pyridin-6-yl)methoxy]-N-(methylsulfonyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: trichlorophosphate / toluene / 3 h / Inert atmosphere; Reflux

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 20 °C / cooling with ice

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 55 °C

3.2: 18 h / 20 °C

3.3: pH 6

With lithium aluminium tetrahydride; sodium hydride; trichlorophosphate; In tetrahydrofuran; toluene; mineral oil;