2-[(1R)-1-hydroxyethyl]phenol

Base Information

• Chemical Name: 2-[(1R)-1-hydroxyethyl]phenol
• CAS No.: 156713-08-5
• Molecular Formula: C₈H₁₀O₂
• Molecular Weight: 138.166
• European Community (EC) Number: 886-415-5
• Nikkaji Number: J2.072.175H
• Mol file: 156713-08-5.mol

Synonyms:2-[(1R)-1-hydroxyethyl]phenol;156713-08-5;(R)-2-(1-Hydroxyethyl)phenol;AKOS012669759;EN300-1836527

Chemical Property of 2-[(1R)-1-hydroxyethyl]phenol

Chemical Property:

• XLogP3: 1.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 138.068079557
• Heavy Atom Count: 10
• Complexity: 103

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C1=CC=CC=C1O)O
• Isomeric SMILES: C[C@H](C1=CC=CC=C1O)O

Technology Process of 2-[(1R)-1-hydroxyethyl]phenol

There total 5 articles about 2-[(1R)-1-hydroxyethyl]phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(1'R,αS)-1-(α-methylbenzyloxy)-2-(1'-hydroxyethyl)benzene (1253208-11-5) → (R)-2?(1?hydroxyethyl)phenol (156713-08-5)

Guidance literature:

With 30% Pd/C; hydrogen; In ethanol; at 20 ℃; for 16h; under 3040.2 Torr;

DOI:10.1016/j.tet.2010.07.058

Reference yield: 91.0%

o-hydroxyacetophenone (118-93-4,104809-67-8) → (R)-2?(1?hydroxyethyl)phenol (156713-08-5)

Guidance literature:

With dichloro(benzene)ruthenium(II) dimer; formic acid; (1R,2R)-N-{1,2-diphenyl-2-[(furan-2-ylmethyl)amino]ethyl}-4-methylbenzene sulfonamide; triethylamine; at 20 ℃;

DOI:10.1021/acs.orglett.9b02339

Reference yield:

o-hydroxyacetophenone (118-93-4,104809-67-8) → (R)-2?(1?hydroxyethyl)phenol (156713-08-5) + (S)-2?(1?hydroxyethyl)phenol (195257-74-0)

Guidance literature:

With C₁₀H₂₂N₂*C₄₄H₃₂Cl₂P₂Ru; hydrogen; potassium hydroxide; In isopropyl alcohol; at 20 ℃; for 12h; under 22502.3 Torr; optical yield given as %ee; enantioselective reaction;

DOI:10.1016/j.cclet.2010.09.025

upstream raw materials:

o-hydroxyacetophenone

2-(1-hydroxyethyl)phenol

(1'R,αS)-1-(α-methylbenzyloxy)-2-(1'-hydroxyethyl)benzene

o-Hydroxyethylbenzene

Downstream raw materials:

(R)-1-(2-methoxyphenyl)ethanol