4-{(Z)-(3S,4R)-5-(tert-butyldimethylsilyloxy)-3-[4-(tert-butyldimethylsilyloxy)phenyl]-4-hydroxy-pent-1-enyl}phenol

Base Information

Chemical Name:4-{(Z)-(3S,4R)-5-(tert-butyldimethylsilyloxy)-3-[4-(tert-butyldimethylsilyloxy)phenyl]-4-hydroxy-pent-1-enyl}phenol
CAS No.:929288-87-9
Molecular Formula:C₂₉H₄₆O₄Si₂
Molecular Weight:514.853
Hs Code.:

Synonyms:4-{(Z)-(3S,4R)-5-(tert-butyldimethylsilyloxy)-3-[4-(tert-butyldimethylsilyloxy)phenyl]-4-hydroxy-pent-1-enyl}phenol

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Chemical Property of 4-{(Z)-(3S,4R)-5-(tert-butyldimethylsilyloxy)-3-[4-(tert-butyldimethylsilyloxy)phenyl]-4-hydroxy-pent-1-enyl}phenol

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Technology Process of 4-{(Z)-(3S,4R)-5-(tert-butyldimethylsilyloxy)-3-[4-(tert-butyldimethylsilyloxy)phenyl]-4-hydroxy-pent-1-enyl}phenol

There total 8 articles about 4-{(Z)-(3S,4R)-5-(tert-butyldimethylsilyloxy)-3-[4-(tert-butyldimethylsilyloxy)phenyl]-4-hydroxy-pent-1-enyl}phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 2,2-dimethylpropionic acid 4-{5-(tert-butyldimethylsilyloxy)-3-[4-(tert-butyldimethylsilanyloxy)phenyl]-4-hydroxy-pent-1-enyl}-phenyl ester

: 929288-87-9
4-{(Z)-(3S,4R)-5-(tert-butyldimethylsilyloxy)-3-[4-(tert-butyldimethylsilyloxy)phenyl]-4-hydroxy-pent-1-enyl}phenol

Guidance literature:: With lithium borohydride; In tetrahydrofuran; at 20 ℃;
DOI:10.1002/anie.200603659

Reference yield:

: 929288-80-2
B-[trans-2-(4-(tert-butyldimethylsilyloxy)phenyl)-vinyl]-9-borabicyclo(3,3,1)nonane

: 929288-87-9
4-{(Z)-(3S,4R)-5-(tert-butyldimethylsilyloxy)-3-[4-(tert-butyldimethylsilyloxy)phenyl]-4-hydroxy-pent-1-enyl}phenol

Guidance literature:: Multi-step reaction with 2 steps

1.1: LiN(Si(CH)3)2 / CH₂Cl₂; tetrahydrofuran / 0.5 h / -78 °C

1.2: tetrahydrofuran; CH₂Cl₂ / 0.67 h / -100 °C

1.3: 72 percent / tetrahydrofuran; CH₂Cl₂ / -100 - -78 °C

2.1: 85 percent / LiBH₄ / tetrahydrofuran / 20 °C

With lithium borohydride; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;
DOI:10.1002/anie.200603659

Reference yield:

: (1R,3R,4S)-2-[4-(2,2-dimethylpropionyloxy)benzyl]-3-[(1R,4S)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]-2-thioniabicyclo[2.2.1]heptane tetrafluoroborate

: 929288-87-9
4-{(Z)-(3S,4R)-5-(tert-butyldimethylsilyloxy)-3-[4-(tert-butyldimethylsilyloxy)phenyl]-4-hydroxy-pent-1-enyl}phenol

Guidance literature:: Multi-step reaction with 2 steps

1.1: LiN(Si(CH)3)2 / CH₂Cl₂; tetrahydrofuran / 0.5 h / -78 °C

1.2: tetrahydrofuran; CH₂Cl₂ / 0.67 h / -100 °C

1.3: 72 percent / tetrahydrofuran; CH₂Cl₂ / -100 - -78 °C

2.1: 85 percent / LiBH₄ / tetrahydrofuran / 20 °C

With lithium borohydride; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;
DOI:10.1002/anie.200603659