exo-5-Amino-cis-hexahydro-cyclopenta[c]pyrrole-2-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: exo-5-Amino-cis-hexahydro-cyclopenta[c]pyrrole-2-carboxylic acid tert-butyl ester
• CAS No.: 1221439-83-3
• Molecular Formula: C₁₂H₂₂N₂O₂
• Molecular Weight: 226.319
• Mol file: 1221439-83-3.mol

Synonyms:tert-butyl (3aR,5s,6aS)-5-amino-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-2-carboxylate

Chemical Property of exo-5-Amino-cis-hexahydro-cyclopenta[c]pyrrole-2-carboxylic acid tert-butyl ester

Chemical Property:

• Boiling Point: 313.2±35.0 °C(Predicted)
• PKA: 10.62±0.20(Predicted)
• Density: 1.084±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

trans-5-Amino-2-Boc-hexahydro-cyclopenta[c]pyrrole 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of exo-5-Amino-cis-hexahydro-cyclopenta[c]pyrrole-2-carboxylic acid tert-butyl ester

There total 6 articles about exo-5-Amino-cis-hexahydro-cyclopenta[c]pyrrole-2-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

tert-butyl (3aR,5s,6aS)-5-azido-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-2-carboxylate (1256039-48-1) → tert-butyl (3aR,5s,6aS)-5-amino-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-2-carboxylate (1221439-83-3,1031335-28-0)

Guidance literature:

With 25% palladium hydroxide on carbon; hydrogen; In methanol; for 16h; Inert atmosphere;

Reference yield: 59.9%

tert-butyl (3aR,5s,6aS)-5-(benzylamino)hexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate → tert-butyl (3aR,5s,6aS)-5-amino-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-2-carboxylate (1221439-83-3,1031335-28-0)

Guidance literature:

With palladium on activated charcoal; ammonium formate; In ethanol; at 80 ℃;

Reference yield:

tert-butyl (3aR,5r,6aS)-5-hydroxy-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-2-carboxylate (912563-48-5) → tert-butyl (3aR,5s,6aS)-5-amino-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-2-carboxylate (1221439-83-3,1031335-28-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium azide / N,N-dimethyl-formamide / 2 h / 90 °C

2: hydrogen / Lindlar catalyst / ethanol / 3 h / 20 °C / 1034.32 Torr

With sodium azide; hydrogen; Lindlar catalyst; In ethanol; N,N-dimethyl-formamide;

upstream raw materials:

tert-butyl (3aR,5s,6aS)-5-azido-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-2-carboxylate

tert-butyl (3aR,5r,6aS)-5-hydroxy-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-2-carboxylate

tert-butyl (3aR,5r,6aS)-5-hydroxy-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-2-carboxylate

(3aR,6aS)-tert-butyl 5-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1221439-83-3 exo-5-Amino-cis-hexahydro-cyclopenta[c]pyrrole-2-carboxylic acid tert-butyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send