3-[(Adamantan-1-yloxy)-(1-benzyloxycarbonylamino-2-phenyl-ethyl)-phosphinoyl]-2-methyl-propionic acid ethyl ester

Base Information

• Chemical Name: 3-[(Adamantan-1-yloxy)-(1-benzyloxycarbonylamino-2-phenyl-ethyl)-phosphinoyl]-2-methyl-propionic acid ethyl ester
• CAS No.: 181506-72-9
• Molecular Formula: C₃₂H₄₂NO₆P
• Molecular Weight: 567.662

Synonyms:3-[(Adamantan-1-yloxy)-(1-benzyloxycarbonylamino-2-phenyl-ethyl)-phosphinoyl]-2-methyl-propionic acid ethyl ester

Chemical Property of 3-[(Adamantan-1-yloxy)-(1-benzyloxycarbonylamino-2-phenyl-ethyl)-phosphinoyl]-2-methyl-propionic acid ethyl ester

Chemical Property:

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Technology Process of 3-[(Adamantan-1-yloxy)-(1-benzyloxycarbonylamino-2-phenyl-ethyl)-phosphinoyl]-2-methyl-propionic acid ethyl ester

There total 3 articles about 3-[(Adamantan-1-yloxy)-(1-benzyloxycarbonylamino-2-phenyl-ethyl)-phosphinoyl]-2-methyl-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl methacrylate (97-63-2,9003-42-3) → 3-[(Adamantan-1-yloxy)-(1-benzyloxycarbonylamino-2-phenyl-ethyl)-phosphinoyl]-2-methyl-propionic acid ethyl ester (181506-72-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) hexamethyldisilazane / 1) 110 deg C, 1 h, 2) 90 deg C, 4 h

2: Ag₂O / CHCl₃ / 1.33 h / Heating

With 1,1,1,3,3,3-hexamethyl-disilazane; silver(l) oxide; In chloroform;

DOI:10.1021/jo9603439

Reference yield:

[2-phenyl-1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinic acid (115961-49-4) → 3-[(Adamantan-1-yloxy)-(1-benzyloxycarbonylamino-2-phenyl-ethyl)-phosphinoyl]-2-methyl-propionic acid ethyl ester (181506-72-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) hexamethyldisilazane / 1) 110 deg C, 1 h, 2) 90 deg C, 4 h

2: Ag₂O / CHCl₃ / 1.33 h / Heating

With 1,1,1,3,3,3-hexamethyl-disilazane; silver(l) oxide; In chloroform;

DOI:10.1021/jo9603439

Reference yield:

1-Adamantyl bromide (768-90-1) + 3-[(1-Benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoyl]-2-methyl-propionic acid ethyl ester (181506-71-8) → 3-[(Adamantan-1-yloxy)-(1-benzyloxycarbonylamino-2-phenyl-ethyl)-phosphinoyl]-2-methyl-propionic acid ethyl ester (181506-72-9)

Guidance literature:

With silver(l) oxide; In chloroform; for 1.33333h; Heating;

DOI:10.1021/jo9603439

upstream raw materials:

1-Adamantyl bromide

3-[(1-Benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoyl]-2-methyl-propionic acid ethyl ester

methyl methacrylate

[2-phenyl-1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinic acid

Downstream raw materials:

3-[(Adamantan-1-yloxy)-(1-benzyloxycarbonylamino-2-phenyl-ethyl)-phosphinoyl]-2-methyl-propionic acid

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