diethyl <(2,3,4-trifluoroanilino)<(4-methoxybenzyl)thio>methylene>malonate

Base Information

Chemical Name:diethyl <(2,3,4-trifluoroanilino)<(4-methoxybenzyl)thio>methylene>malonate
CAS No.:119474-33-8
Molecular Formula:C₂₂H₂₂F₃NO₅S
Molecular Weight:469.482
Hs Code.:

Synonyms:diethyl <(2,3,4-trifluoroanilino)<(4-methoxybenzyl)thio>methylene>malonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of diethyl <(2,3,4-trifluoroanilino)<(4-methoxybenzyl)thio>methylene>malonate

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Technology Process of diethyl <(2,3,4-trifluoroanilino)<(4-methoxybenzyl)thio>methylene>malonate

There total 4 articles about diethyl <(2,3,4-trifluoroanilino)<(4-methoxybenzyl)thio>methylene>malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 824-94-2
p-methoxybenzyl chloride

: sodium diethyl <(2,3,4-trifluoroanilino)sulfidomethylene>malonate

: 119474-33-8
diethyl <(2,3,4-trifluoroanilino)<(4-methoxybenzyl)thio>methylene>malonate

Guidance literature:: In N,N-dimethyl-formamide; for 1h; Ambient temperature;
DOI:10.1021/jm00070a005

Reference yield:

: [(2,3,4-trifluoroanilino)(p-methoxybenzylthio)methylene]malonate

: 824-94-2
p-methoxybenzyl chloride

: sodium diethyl <(2,3,4-trifluoroanilino)sulfidomethylene>malonate

: 119474-33-8
diethyl <(2,3,4-trifluoroanilino)<(4-methoxybenzyl)thio>methylene>malonate

Guidance literature:: In water; N,N-dimethyl-formamide;

Reference yield:

: 119474-39-4
triethylammonium N-(2,3,4-trifluorophenyl)dithiocarbamate

: 119474-33-8
diethyl <(2,3,4-trifluoroanilino)<(4-methoxybenzyl)thio>methylene>malonate

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / triethylamine, ethyl chloroformate / CHCl₃ / 0.17 h / 2 - 6 °C

2: 1.) sodium hydride / 1.) THF, 5-10 deg C, 10 min, 2.) THF, RT, 105 min

3: 95 percent / dimethylformamide / 1 h / Ambient temperature

With chloroformic acid ethyl ester; sodium hydride; triethylamine; In chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm00070a005