(2S,3R,4S,10S,11S,14S)-1,9-Bis-benzenesulfonyl-3,11-bis-(tert-butyl-dimethyl-silanyloxy)-2,4,10,14-tetramethyl-hexadec-15-en-7-one

Base Information

Chemical Name:(2S,3R,4S,10S,11S,14S)-1,9-Bis-benzenesulfonyl-3,11-bis-(tert-butyl-dimethyl-silanyloxy)-2,4,10,14-tetramethyl-hexadec-15-en-7-one
CAS No.:189832-24-4
Molecular Formula:C₄₄H₇₄O₇S₂Si₂
Molecular Weight:835.37
Hs Code.:

Synonyms:(2S,3R,4S,10S,11S,14S)-1,9-Bis-benzenesulfonyl-3,11-bis-(tert-butyl-dimethyl-silanyloxy)-2,4,10,14-tetramethyl-hexadec-15-en-7-one

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Chemical Property of (2S,3R,4S,10S,11S,14S)-1,9-Bis-benzenesulfonyl-3,11-bis-(tert-butyl-dimethyl-silanyloxy)-2,4,10,14-tetramethyl-hexadec-15-en-7-one

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Technology Process of (2S,3R,4S,10S,11S,14S)-1,9-Bis-benzenesulfonyl-3,11-bis-(tert-butyl-dimethyl-silanyloxy)-2,4,10,14-tetramethyl-hexadec-15-en-7-one

There total 21 articles about (2S,3R,4S,10S,11S,14S)-1,9-Bis-benzenesulfonyl-3,11-bis-(tert-butyl-dimethyl-silanyloxy)-2,4,10,14-tetramethyl-hexadec-15-en-7-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 189832-23-3
(2S,3R,4S,10S,11S,14S)-1,9-Bis-benzenesulfonyl-3,11-bis-(tert-butyl-dimethyl-silanyloxy)-2,4,10,14-tetramethyl-hexadec-15-en-7-ol

: 189832-24-4
(2S,3R,4S,10S,11S,14S)-1,9-Bis-benzenesulfonyl-3,11-bis-(tert-butyl-dimethyl-silanyloxy)-2,4,10,14-tetramethyl-hexadec-15-en-7-one

Guidance literature:: With 4 A molecular sieve; pyridinium chlorochromate; In dichloromethane; for 40h; Ambient temperature;
DOI:10.1016/S0040-4020(97)00229-9

Reference yield:

: 168333-75-3
(2S,3R,4S)-1-Benzenesulfonyl-2,4-dimethyl-oct-7-en-3-ol

: 189832-24-4
(2S,3R,4S,10S,11S,14S)-1,9-Bis-benzenesulfonyl-3,11-bis-(tert-butyl-dimethyl-silanyloxy)-2,4,10,14-tetramethyl-hexadec-15-en-7-one

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / 2,6-lutidine / CH₂Cl₂ / 2.5 h / Ambient temperature

2: 82 percent / MCPBA, Na₂HPO₄ / CH₂Cl₂ / 5 h / Ambient temperature

3: 1.) n-BuLi, 2.) BF₃*Et₂O / 1.) hexane, THF, -78 deg C, 30 min, 2.) -78 deg C, 2 h.

4: 89 percent / PCC, molecular sieve 4 Angstroem / CH₂Cl₂ / 40 h / Ambient temperature

With 2,6-dimethylpyridine; disodium hydrogenphosphate; n-butyllithium; 4 A molecular sieve; boron trifluoride diethyl etherate; 3-chloro-benzenecarboperoxoic acid; pyridinium chlorochromate; In dichloromethane;
DOI:10.1016/S0040-4020(97)00229-9

Reference yield:

: 168333-74-2
(2R,3S,6S)-2-((S)-2-Benzenesulfonyl-1-methyl-ethyl)-6-iodomethyl-3-methyl-tetrahydro-pyran

: 189832-24-4
(2S,3R,4S,10S,11S,14S)-1,9-Bis-benzenesulfonyl-3,11-bis-(tert-butyl-dimethyl-silanyloxy)-2,4,10,14-tetramethyl-hexadec-15-en-7-one

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / Zn / aq. ethanol; pyridine / 70 °C

2: 80 percent / 2,6-lutidine / CH₂Cl₂ / 2.5 h / Ambient temperature

3: 82 percent / MCPBA, Na₂HPO₄ / CH₂Cl₂ / 5 h / Ambient temperature

4: 1.) n-BuLi, 2.) BF₃*Et₂O / 1.) hexane, THF, -78 deg C, 30 min, 2.) -78 deg C, 2 h.

5: 89 percent / PCC, molecular sieve 4 Angstroem / CH₂Cl₂ / 40 h / Ambient temperature

With 2,6-dimethylpyridine; disodium hydrogenphosphate; n-butyllithium; 4 A molecular sieve; boron trifluoride diethyl etherate; 3-chloro-benzenecarboperoxoic acid; pyridinium chlorochromate; zinc; In pyridine; ethanol; dichloromethane;
DOI:10.1016/S0040-4020(97)00229-9