(3S)-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(4-fluorophenol)propanoic acid

Base Information

Chemical Name:(3S)-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(4-fluorophenol)propanoic acid
CAS No.:852443-89-1
Molecular Formula:C₁₇H₁₂FNO₄
Molecular Weight:313.285
Hs Code.:

Synonyms:(3S)-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(4-fluorophenol)propanoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3S)-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(4-fluorophenol)propanoic acid

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Technology Process of (3S)-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(4-fluorophenol)propanoic acid

There total 1 articles about (3S)-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(4-fluorophenol)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 85-44-9
phthalic anhydride

: 151911-33-0
(S)-β-amino-β-(4-fluorophenyl)propionic acid

: 852443-89-1
(3S)-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(4-fluorophenol)propanoic acid

Guidance literature:: In DMF (N,N-dimethyl-formamide); at 135 ℃;

Reference yield: 91.0%

: 852443-89-1
(3S)-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(4-fluorophenol)propanoic acid

: 852443-88-0
C₁₆H₁₁FN₄O₂

Guidance literature:: (3S)-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(4-fluorophenol)propanoic acid; With chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; at 0 ℃; for 1h;

With sodium azide; In tetrahydrofuran; water; for 1h;

In toluene; at 110 ℃; for 1.5h;