3-hydroxy-O-methyl-N-<4-iodo-N-<(1,1-dimethylethoxy)carbonyl>-L-phenylalanyl>-L-tyrosine methyl ester

Base Information

Chemical Name:3-hydroxy-O-methyl-N-<4-iodo-N-<(1,1-dimethylethoxy)carbonyl>-L-phenylalanyl>-L-tyrosine methyl ester
CAS No.:1026064-05-0
Molecular Formula:C₂₅H₃₁IN₂O₇
Molecular Weight:598.435
Hs Code.:

Synonyms:3-hydroxy-O-methyl-N-<4-iodo-N-<(1,1-dimethylethoxy)carbonyl>-L-phenylalanyl>-L-tyrosine methyl ester

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Chemical Property of 3-hydroxy-O-methyl-N-<4-iodo-N-<(1,1-dimethylethoxy)carbonyl>-L-phenylalanyl>-L-tyrosine methyl ester

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Technology Process of 3-hydroxy-O-methyl-N-<4-iodo-N-<(1,1-dimethylethoxy)carbonyl>-L-phenylalanyl>-L-tyrosine methyl ester

There total 5 articles about 3-hydroxy-O-methyl-N-<4-iodo-N-<(1,1-dimethylethoxy)carbonyl>-L-phenylalanyl>-L-tyrosine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 37466-41-4
3-Hydroxy-4-methoxy-L-phenylalanine methyl ester

: 103882-09-3,62129-44-6
N-Boc-4-I-Phe-OH

: 1026064-05-0
3-hydroxy-O-methyl-N-<4-iodo-N-<(1,1-dimethylethoxy)carbonyl>-L-phenylalanyl>-L-tyrosine methyl ester

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 25 ℃; for 16h;
DOI:10.1021/ja00077a047

Reference yield:

: 110774-03-3
L-3-(3-acetyl-4-hydroxyphenyl)-N-(benzyloxycarbonyl)alanine methyl ester

: 1026064-05-0
3-hydroxy-O-methyl-N-<4-iodo-N-<(1,1-dimethylethoxy)carbonyl>-L-phenylalanyl>-L-tyrosine methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 94 percent / K₂CO₃ / dimethylformamide / 6 h / 25 °C

2: 96 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 20 h / 40 °C

3: 97 percent / 0.25 N HCl-CH₃OH / 10 h / 25 °C

4: 99 percent / H₂ / 10percent Pd/C / methanol / 10 h / 25 °C / 760 Torr

5: 95 percent / EDCI, HOBt / dimethylformamide / 16 h / 25 °C

With hydrogenchloride; hydrogen; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja00077a047

Reference yield:

: 79677-60-4
3-acetyl-O-methyl-N-<(phenylmethoxy)carbonyl>-L-tyrosine methyl ester

: 1026064-05-0
3-hydroxy-O-methyl-N-<4-iodo-N-<(1,1-dimethylethoxy)carbonyl>-L-phenylalanyl>-L-tyrosine methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 20 h / 40 °C

2: 97 percent / 0.25 N HCl-CH₃OH / 10 h / 25 °C

3: 99 percent / H₂ / 10percent Pd/C / methanol / 10 h / 25 °C / 760 Torr

4: 95 percent / EDCI, HOBt / dimethylformamide / 16 h / 25 °C

With hydrogenchloride; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja00077a047