6-fluoro-7-(2-fluoro-4-iodo-phenylamino)-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid (2-hydroxy-ethoxy)-amide

Base Information

Chemical Name:6-fluoro-7-(2-fluoro-4-iodo-phenylamino)-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid (2-hydroxy-ethoxy)-amide
CAS No.:1150098-26-2
Molecular Formula:C₁₇H₁₆F₂IN₃O₄
Molecular Weight:491.233
Hs Code.:

Synonyms:6-fluoro-7-(2-fluoro-4-iodo-phenylamino)-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid (2-hydroxy-ethoxy)-amide

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Chemical Property of 6-fluoro-7-(2-fluoro-4-iodo-phenylamino)-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid (2-hydroxy-ethoxy)-amide

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Technology Process of 6-fluoro-7-(2-fluoro-4-iodo-phenylamino)-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid (2-hydroxy-ethoxy)-amide

There total 2 articles about 6-fluoro-7-(2-fluoro-4-iodo-phenylamino)-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid (2-hydroxy-ethoxy)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1150098-27-3
6-fluoro-7-(2-fluoro-4-iodo-phenylamino)-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid (2-tert-butoxy-ethoxy)-amide

: 1150098-26-2
6-fluoro-7-(2-fluoro-4-iodo-phenylamino)-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid (2-hydroxy-ethoxy)-amide

Guidance literature:: With trifluoroacetic acid; at 20 ℃; for 1h;

Reference yield: 26.0%

: 1193488-48-0
6-Fluoro-7-(2-fluoro-4-iodo-phenylamino)-5-oxo-1,2,3,1-tetrahydro-indolizine-8-carboxylic acid (2-vinyloxy-ethoxy)-amide

: 1150098-26-2
6-fluoro-7-(2-fluoro-4-iodo-phenylamino)-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid (2-hydroxy-ethoxy)-amide

Guidance literature:: 6-Fluoro-7-(2-fluoro-4-iodo-phenylamino)-5-oxo-1,2,3,1-tetrahydro-indolizine-8-carboxylic acid (2-vinyloxy-ethoxy)-amide; With hydrogenchloride; In tetrahydrofuran; ethanol; water; at 90 ℃;

With sodium hydroxide; In water; pH=6;

Reference yield: 60.0%

: 1150098-26-2
6-fluoro-7-(2-fluoro-4-iodo-phenylamino)-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid (2-hydroxy-ethoxy)-amide

: 1066-54-2
trimethylsilylacetylene

: 1150098-42-2
7-(4-Ethynyl-2-fluorophenylamino)-6-fluoro-N-(2-hydroxyethoxy)-5-oxo-1,2,3,5-tetrahydroindolizine-8-carboxamide

Guidance literature:: 6-fluoro-7-(2-fluoro-4-iodo-phenylamino)-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid (2-hydroxy-ethoxy)-amide; trimethylsilylacetylene; With triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 3h;

With potassium carbonate; In tetrahydrofuran; methanol; for 1h;