(E)-6-{trifluoromethanesulfonyl-[2-trifluoromethanesulfonyloxy-3-(trimethylsilyl)benzyl]amino}hex-2-en-4-ynoic acid methyl ester

Base Information

Chemical Name:(E)-6-{trifluoromethanesulfonyl-[2-trifluoromethanesulfonyloxy-3-(trimethylsilyl)benzyl]amino}hex-2-en-4-ynoic acid methyl ester
CAS No.:866041-41-0
Molecular Formula:C₁₉H₂₁F₆NO₇S₂Si
Molecular Weight:581.586
Hs Code.:

Synonyms:(E)-6-{trifluoromethanesulfonyl-[2-trifluoromethanesulfonyloxy-3-(trimethylsilyl)benzyl]amino}hex-2-en-4-ynoic acid methyl ester

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Chemical Property of (E)-6-{trifluoromethanesulfonyl-[2-trifluoromethanesulfonyloxy-3-(trimethylsilyl)benzyl]amino}hex-2-en-4-ynoic acid methyl ester

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Technology Process of (E)-6-{trifluoromethanesulfonyl-[2-trifluoromethanesulfonyloxy-3-(trimethylsilyl)benzyl]amino}hex-2-en-4-ynoic acid methyl ester

There total 6 articles about (E)-6-{trifluoromethanesulfonyl-[2-trifluoromethanesulfonyloxy-3-(trimethylsilyl)benzyl]amino}hex-2-en-4-ynoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 866041-64-7
(E)-6-[2-hydroxy-3-(trimethylsilyl)benzylamino]hex-2-en-4-ynoic acid methyl ester

: 358-23-6
trifluoromethylsulfonic anhydride

: 866041-41-0
(E)-6-{trifluoromethanesulfonyl-[2-trifluoromethanesulfonyloxy-3-(trimethylsilyl)benzyl]amino}hex-2-en-4-ynoic acid methyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at -78 ℃; for 1h;
DOI:10.1021/ol051372l

Reference yield:

: 866041-35-2
2-[(prop-2-ynylamino)methyl]-6-(trimethylsilyl)phenol

: 866041-41-0
(E)-6-{trifluoromethanesulfonyl-[2-trifluoromethanesulfonyloxy-3-(trimethylsilyl)benzyl]amino}hex-2-en-4-ynoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / CuI; (i-Pr)2NEt / (Ph₃P)2PdCl₂ / tetrahydrofuran / 4 h / 20 °C

2: 88 percent / (i-Pr₂)NEt / CH₂Cl₂ / 1 h / -78 °C

With copper(l) iodide; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; dichloromethane; 1: Sonogashira cross-coupling;
DOI:10.1021/ol051372l

Reference yield:

: 824-91-9
O-methoxymethylphenol

: 866041-41-0
(E)-6-{trifluoromethanesulfonyl-[2-trifluoromethanesulfonyloxy-3-(trimethylsilyl)benzyl]amino}hex-2-en-4-ynoic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 2 h / 0 °C

1.2: tetrahydrofuran; hexane / 0 - 20 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 2 h / 0 °C

2.2: 87 percent / tetrahydrofuran; hexane / -78 - 20 °C

3.1: 97 percent / NaI; HCl / acetone; H₂O / 0.75 h / 55 °C

4.1: molecular sieves 3 Angstroem / methanol / 0.5 h / 20 °C

4.2: 83 percent / NaBH₄ / methanol / 1 h / 0 °C

5.1: 75 percent / CuI; (i-Pr)2NEt / (Ph₃P)2PdCl₂ / tetrahydrofuran / 4 h / 20 °C

6.1: 88 percent / (i-Pr₂)NEt / CH₂Cl₂ / 1 h / -78 °C

With hydrogenchloride; copper(l) iodide; n-butyllithium; 3 A molecular sieve; N-ethyl-N,N-diisopropylamine; sodium iodide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; methanol; hexane; dichloromethane; water; acetone; 5.1: Sonogashira cross-coupling;
DOI:10.1021/ol051372l