(2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[6-[2-(4-nitro-phenyl)-ethoxy]-2-(3-[2,2';5',2'']terthiophen-5-yl-propylamino)-purin-9-yl]-tetrahydro-furan-3-ol

Base Information

Chemical Name:(2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[6-[2-(4-nitro-phenyl)-ethoxy]-2-(3-[2,2';5',2'']terthiophen-5-yl-propylamino)-purin-9-yl]-tetrahydro-furan-3-ol
CAS No.:866455-95-0
Molecular Formula:C₅₄H₅₀N₆O₈S₃
Molecular Weight:1007.22
Hs Code.:

(2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[6-[2-(4-nitro-phenyl)-ethoxy]-2-(3-[2,2';5',2'']terthiophen-5-yl-propylamino)-purin-9-yl]-tetrahydro-furan-3-ol

Synonyms:(2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[6-[2-(4-nitro-phenyl)-ethoxy]-2-(3-[2,2';5',2'']terthiophen-5-yl-propylamino)-purin-9-yl]-tetrahydro-furan-3-ol

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Chemical Property of (2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[6-[2-(4-nitro-phenyl)-ethoxy]-2-(3-[2,2';5',2'']terthiophen-5-yl-propylamino)-purin-9-yl]-tetrahydro-furan-3-ol

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Technology Process of (2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[6-[2-(4-nitro-phenyl)-ethoxy]-2-(3-[2,2';5',2'']terthiophen-5-yl-propylamino)-purin-9-yl]-tetrahydro-furan-3-ol

There total 6 articles about (2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[6-[2-(4-nitro-phenyl)-ethoxy]-2-(3-[2,2';5',2'']terthiophen-5-yl-propylamino)-purin-9-yl]-tetrahydro-furan-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 866455-94-9
(2R,3S,5R)-2-Hydroxymethyl-5-[6-[2-(4-nitro-phenyl)-ethoxy]-2-(3-[2,2';5',2'']terthiophen-5-yl-propylamino)-purin-9-yl]-tetrahydro-furan-3-ol

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 866455-95-0
(2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[6-[2-(4-nitro-phenyl)-ethoxy]-2-(3-[2,2';5',2'']terthiophen-5-yl-propylamino)-purin-9-yl]-tetrahydro-furan-3-ol

Guidance literature:: With pyridine; at 20 ℃; for 48h;
DOI:10.1016/j.bmcl.2005.07.004

Reference yield:

: (E)-3-[2,2';5',2'']Terthiophen-5-yl-acrylonitrile

: 866455-95-0
(2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[6-[2-(4-nitro-phenyl)-ethoxy]-2-(3-[2,2';5',2'']terthiophen-5-yl-propylamino)-purin-9-yl]-tetrahydro-furan-3-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 80 percent / H₂ / Pd/C / toluene / 22 h / 20 °C

2: 90 percent / LiAlH₄ / diethyl ether / 15 h / 20 °C

3: 30 percent / pyridine / 72 h / 20 °C

4: 80 percent / Et₃N*3HF / tetrahydrofuran / 48 h / 20 °C

5: 32 percent / pyridine / 48 h / 20 °C

With pyridine; lithium aluminium tetrahydride; hydrogen; triethylamine tris(hydrogen fluoride); palladium on activated charcoal; In tetrahydrofuran; pyridine; diethyl ether; toluene;
DOI:10.1016/j.bmcl.2005.07.004

Reference yield:

: 7342-41-8
2,2':5',2''-terthiophene-5-carboxaldehyde

: 866455-95-0
(2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[6-[2-(4-nitro-phenyl)-ethoxy]-2-(3-[2,2';5',2'']terthiophen-5-yl-propylamino)-purin-9-yl]-tetrahydro-furan-3-ol

Guidance literature:: Multi-step reaction with 6 steps

1: tetrahydrofuran / 12 h / Heating

2: 80 percent / H₂ / Pd/C / toluene / 22 h / 20 °C

3: 90 percent / LiAlH₄ / diethyl ether / 15 h / 20 °C

4: 30 percent / pyridine / 72 h / 20 °C

5: 80 percent / Et₃N*3HF / tetrahydrofuran / 48 h / 20 °C

6: 32 percent / pyridine / 48 h / 20 °C

With pyridine; lithium aluminium tetrahydride; hydrogen; triethylamine tris(hydrogen fluoride); palladium on activated charcoal; In tetrahydrofuran; pyridine; diethyl ether; toluene;
DOI:10.1016/j.bmcl.2005.07.004