Technology Process of (+/-)-3,6-bis(3,5-diphenylphenyl)-1,2,3,6,7,8-hexahydro-as-indacene-4,5-diol
There total 15 articles about (+/-)-3,6-bis(3,5-diphenylphenyl)-1,2,3,6,7,8-hexahydro-as-indacene-4,5-diol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
boron tribromide;
In
dichloromethane;
at -78 - 20 ℃;
for 12h;
DOI:10.1021/jo00265a049
- Guidance literature:
-
Multi-step reaction with 11 steps
1: stannic chloride / CH2Cl2 / 1.) 0 deg C, 1 h, 2.) RT, 15 min
2: 1.) sodium hydride / 1.) THF, 2.) reflux, 3 h
3: NaOH / methanol; H2O / 5 h / Heating
4: 30 h / 200 °C
5: conc. H2SO4 / 4 h / Heating
6: 72 percent / FeCl3, Br2 / CCl4 / Heating
7: aq. NaOH / aq. ethanol / 2 h / Heating
8: t-BuLi / tetrahydrofuran; hexane / 20 h / -78 °C
10: 48 percent / triethylsilane, trifluoroacetic acid / CH2Cl2 / 0.17 h / Ambient temperature
11: 90 percent / boron tribromide / CH2Cl2 / 12 h / -78 - 20 °C
With
triethylsilane; sodium hydroxide; sulfuric acid; bromine; tert.-butyl lithium; boron tribromide; iron(III) chloride; tin(IV) chloride; sodium hydride; trifluoroacetic acid;
In
tetrahydrofuran; methanol; tetrachloromethane; ethanol; hexane; dichloromethane; water;
DOI:10.1021/jo00265a049
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 1.) sodium hydride / 1.) THF, 2.) reflux, 3 h
2: NaOH / methanol; H2O / 5 h / Heating
3: 30 h / 200 °C
4: conc. H2SO4 / 4 h / Heating
5: 72 percent / FeCl3, Br2 / CCl4 / Heating
6: aq. NaOH / aq. ethanol / 2 h / Heating
7: t-BuLi / tetrahydrofuran; hexane / 20 h / -78 °C
9: 48 percent / triethylsilane, trifluoroacetic acid / CH2Cl2 / 0.17 h / Ambient temperature
10: 90 percent / boron tribromide / CH2Cl2 / 12 h / -78 - 20 °C
With
triethylsilane; sodium hydroxide; sulfuric acid; bromine; tert.-butyl lithium; boron tribromide; iron(III) chloride; sodium hydride; trifluoroacetic acid;
In
tetrahydrofuran; methanol; tetrachloromethane; ethanol; hexane; dichloromethane; water;
DOI:10.1021/jo00265a049
