8-METHYL-2-P-TOLYL-IMIDAZO[1,2-A]PYRIDINE-3-CARBOXALDEHYDE

Base Information

• Chemical Name: 8-METHYL-2-P-TOLYL-IMIDAZO[1,2-A]PYRIDINE-3-CARBOXALDEHYDE
• CAS No.: 524724-74-1
• Molecular Formula: C₁₆H₁₄N₂O
• Molecular Weight: 250.3
• Mol file: 524724-74-1.mol

Synonyms:8-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-carbaldehyde

Chemical Property of 8-METHYL-2-P-TOLYL-IMIDAZO[1,2-A]PYRIDINE-3-CARBOXALDEHYDE

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

8-Methyl-2-p-tolyl-imidazo[1,2-a]pyridine-3-carboxaldehyde 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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Technology Process of 8-METHYL-2-P-TOLYL-IMIDAZO[1,2-A]PYRIDINE-3-CARBOXALDEHYDE

There total 4 articles about 8-METHYL-2-P-TOLYL-IMIDAZO[1,2-A]PYRIDINE-3-CARBOXALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

8-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine + N,N,N,N,-tetramethylethylenediamine (110-18-9) → 8-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-carbaldehyde (524724-74-1)

Guidance literature:

With water; rose bengal; potassium iodide; In 1,4-dioxane; at 20 ℃; for 36h; Irradiation;

DOI:10.1039/c8ob00532j

Reference yield: 68.0%

8-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 8-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-carbaldehyde (524724-74-1)

Guidance literature:

N,N-dimethyl-formamide; With trichlorophosphate; at 0 - 5 ℃;

8-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine; at 80 ℃; for 6h;

DOI:10.1016/j.bmcl.2013.03.086

Reference yield:

3-methylpyridin-2-ylamine (1603-40-3) → 8-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-carbaldehyde (524724-74-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: ethanol / 6 h / Reflux

2.1: trichlorophosphate / 0 - 5 °C

2.2: 6 h / 80 °C

With trichlorophosphate; In ethanol; 2.1: |Vilsmeier-Haack Formylation;

DOI:10.1016/j.bmcl.2013.03.086

upstream raw materials:

N,N-dimethyl-formamide

3-methylpyridin-2-ylamine

4-(bromoacetyl)toluene

N,N,N,N,-tetramethylethylenediamine

Downstream raw materials:

8-methyl-2-p-tolyl-imidazo[1,2-a]pyridine-3-carbaldehyde-O-prop-2-ynyl oxime

8-methyl-2-p-tolyl-imidazo[1,2-a]pyridine-3-carbaldehyde-O-[1-(4-methylbenzyl)-1H-1,2,3-triazol-4-yl]methyl oxime

8-methyl-2-p-tolyl-imidazo[1,2-a]pyridine-3-carbaldehyde-O-[1-(4-methoxybenzyl)1H-1,2,3-triazol-4-yl]methyl oxime

8-methyl-2-p-tolyl-imidazo[1,2-a]pyridine-3-carbaldehyde-O-[1-(4-nitrobenzyl)-1H-1,2,3-triazol-4-yl]methyl oxime

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